Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture

Aortic intramural hematoma (IMH) can evolve toward reabsorption, dissection or aneurysm. Hypertension is the most common predisposing factor in IMH and aneurysm patients, and the hypertensive mediator angiotensin-II induces both in mice. We have previously shown that constitutive deletion of Rcan1 i...

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Detalles Bibliográficos
Autores principales: Villahoz, Silvia, Yunes-Leites, Paula Sofía, Méndez-Barbero, Nerea, Urso, Katia, Bonzon-Kulichenko, Elena, Ortega, Sagrario, Nistal, J. Francisco, Vazquez, Jesus, Offermanns, Stefan, Redondo, Juan Miguel, Campanero, Miguel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237779/
https://www.ncbi.nlm.nih.gov/pubmed/30442942
http://dx.doi.org/10.1038/s41467-018-07071-7

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