Pemphigus Foliaceus—Repeated Treatment With Rituximab 7 Years After Initial Response: A Case Report

Pemphigus foliaceus is an autoimmune skin disease mediated by autoantibodies directed against desmoglein-1 located in the upper epidermal layer. Rituximab, a monoclonal anit-CD20 antibody depleting b-cells, offers an effective treatment possibility for therapy-resistant pemphigus foliaceus. Here, we...

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Detalles Bibliográficos
Autores principales: Kraft, Magdalena, Worm, Margitta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237918/
https://www.ncbi.nlm.nih.gov/pubmed/30474029
http://dx.doi.org/10.3389/fmed.2018.00315
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author Kraft, Magdalena
Worm, Margitta
author_facet Kraft, Magdalena
Worm, Margitta
author_sort Kraft, Magdalena
collection PubMed
description Pemphigus foliaceus is an autoimmune skin disease mediated by autoantibodies directed against desmoglein-1 located in the upper epidermal layer. Rituximab, a monoclonal anit-CD20 antibody depleting b-cells, offers an effective treatment possibility for therapy-resistant pemphigus foliaceus. Here, we present the case of 55-year-old man who did not respond sufficiently to conventional treatment with prednisolone, azathioprine, and cyclophosphamide, but underwent almost complete remission after rituximab treatment. The patient relapsed 7 years later, and a repeated course of rituximab infusions led to a partial remission.
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spelling pubmed-62379182018-11-23 Pemphigus Foliaceus—Repeated Treatment With Rituximab 7 Years After Initial Response: A Case Report Kraft, Magdalena Worm, Margitta Front Med (Lausanne) Medicine Pemphigus foliaceus is an autoimmune skin disease mediated by autoantibodies directed against desmoglein-1 located in the upper epidermal layer. Rituximab, a monoclonal anit-CD20 antibody depleting b-cells, offers an effective treatment possibility for therapy-resistant pemphigus foliaceus. Here, we present the case of 55-year-old man who did not respond sufficiently to conventional treatment with prednisolone, azathioprine, and cyclophosphamide, but underwent almost complete remission after rituximab treatment. The patient relapsed 7 years later, and a repeated course of rituximab infusions led to a partial remission. Frontiers Media S.A. 2018-11-09 /pmc/articles/PMC6237918/ /pubmed/30474029 http://dx.doi.org/10.3389/fmed.2018.00315 Text en Copyright © 2018 Kraft and Worm. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Kraft, Magdalena
Worm, Margitta
Pemphigus Foliaceus—Repeated Treatment With Rituximab 7 Years After Initial Response: A Case Report
title Pemphigus Foliaceus—Repeated Treatment With Rituximab 7 Years After Initial Response: A Case Report
title_full Pemphigus Foliaceus—Repeated Treatment With Rituximab 7 Years After Initial Response: A Case Report
title_fullStr Pemphigus Foliaceus—Repeated Treatment With Rituximab 7 Years After Initial Response: A Case Report
title_full_unstemmed Pemphigus Foliaceus—Repeated Treatment With Rituximab 7 Years After Initial Response: A Case Report
title_short Pemphigus Foliaceus—Repeated Treatment With Rituximab 7 Years After Initial Response: A Case Report
title_sort pemphigus foliaceus—repeated treatment with rituximab 7 years after initial response: a case report
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237918/
https://www.ncbi.nlm.nih.gov/pubmed/30474029
http://dx.doi.org/10.3389/fmed.2018.00315
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