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The effect of rutin on cisplatin-induced oxidative cardiac damage in rats

OBJECTIVE: Cisplatin is an anticancer drug used for treating childhood solid tumors. Symptoms related to cisplatin-induced cardiovascular adverse effects may be mild or severe. Rutin (vitamin P1) has many properties, including as antioxidant, anticancer, antidiabetic, antimicrobial, antiulcer, and t...

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Autores principales: Topal, İsmail, Bilgin, Aslı Özbek, Çimen, Ferda Keskin, Kurt, Nezahat, Süleyman, Zeynep, Bilgin, Yasin, Özçiçek, Adalet, Altuner, Durdu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237943/
https://www.ncbi.nlm.nih.gov/pubmed/30152807
http://dx.doi.org/10.14744/AnatolJCardiol.2018.32708
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author Topal, İsmail
Bilgin, Aslı Özbek
Çimen, Ferda Keskin
Kurt, Nezahat
Süleyman, Zeynep
Bilgin, Yasin
Özçiçek, Adalet
Altuner, Durdu
author_facet Topal, İsmail
Bilgin, Aslı Özbek
Çimen, Ferda Keskin
Kurt, Nezahat
Süleyman, Zeynep
Bilgin, Yasin
Özçiçek, Adalet
Altuner, Durdu
author_sort Topal, İsmail
collection PubMed
description OBJECTIVE: Cisplatin is an anticancer drug used for treating childhood solid tumors. Symptoms related to cisplatin-induced cardiovascular adverse effects may be mild or severe. Rutin (vitamin P1) has many properties, including as antioxidant, anticancer, antidiabetic, antimicrobial, antiulcer, and tissue renewal properties. Therefore, we aimed to biochemically, histopathologically, and immunohistochemically demonstrate the effect of rutin on cisplatin-induced cardiotoxicity in rats. METHODS: The rats included in our study were divided into four groups: Healthy group (HE), 5-mg/kg cisplatin group (CP), 50 mg/kg rutin+5-mg/kg cisplatin (CR-50), 100-mg/kg rutin+5-mg/kg cisplatin (CR-100) group. RESULTS: CP group administered cisplatin had significantly increased blood, serum, and cardiac tissue malondialdehyde (MDA), interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), troponin I, creatine kinase (CK), and CK-MB levels compared to the HE group, whereas there was a significant decrease in the total glutathione (tGSH) levels. Rutin was observed to prevent the increase in MDA, IL-1β, TNF-α, troponin I, CK, and CK-MB levels as well as prevent the decrease in tGSH levels more significantly when administered at a 100-mg/kg dose than at a 50-mg/kg dose. Histopathologically, cardiac necrosis, dilated/congested blood vessels, hemorrhage, polymorphonuclear leukocyte, edema, and cells with pyknotic nuclei were observed in the CP group. Rutin was shown to prevent cisplatin-induced cardiac damage more effectively when used at a100-mg/kg dose than at a 50-mg/kg dose. CONCLUSION: These results suggest that rutin is useful for preventing cisplatin-related cardiovascular damage
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spelling pubmed-62379432018-11-19 The effect of rutin on cisplatin-induced oxidative cardiac damage in rats Topal, İsmail Bilgin, Aslı Özbek Çimen, Ferda Keskin Kurt, Nezahat Süleyman, Zeynep Bilgin, Yasin Özçiçek, Adalet Altuner, Durdu Anatol J Cardiol Original Investigation OBJECTIVE: Cisplatin is an anticancer drug used for treating childhood solid tumors. Symptoms related to cisplatin-induced cardiovascular adverse effects may be mild or severe. Rutin (vitamin P1) has many properties, including as antioxidant, anticancer, antidiabetic, antimicrobial, antiulcer, and tissue renewal properties. Therefore, we aimed to biochemically, histopathologically, and immunohistochemically demonstrate the effect of rutin on cisplatin-induced cardiotoxicity in rats. METHODS: The rats included in our study were divided into four groups: Healthy group (HE), 5-mg/kg cisplatin group (CP), 50 mg/kg rutin+5-mg/kg cisplatin (CR-50), 100-mg/kg rutin+5-mg/kg cisplatin (CR-100) group. RESULTS: CP group administered cisplatin had significantly increased blood, serum, and cardiac tissue malondialdehyde (MDA), interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), troponin I, creatine kinase (CK), and CK-MB levels compared to the HE group, whereas there was a significant decrease in the total glutathione (tGSH) levels. Rutin was observed to prevent the increase in MDA, IL-1β, TNF-α, troponin I, CK, and CK-MB levels as well as prevent the decrease in tGSH levels more significantly when administered at a 100-mg/kg dose than at a 50-mg/kg dose. Histopathologically, cardiac necrosis, dilated/congested blood vessels, hemorrhage, polymorphonuclear leukocyte, edema, and cells with pyknotic nuclei were observed in the CP group. Rutin was shown to prevent cisplatin-induced cardiac damage more effectively when used at a100-mg/kg dose than at a 50-mg/kg dose. CONCLUSION: These results suggest that rutin is useful for preventing cisplatin-related cardiovascular damage Kare Publishing 2018-09 2018-08-06 /pmc/articles/PMC6237943/ /pubmed/30152807 http://dx.doi.org/10.14744/AnatolJCardiol.2018.32708 Text en Copyright: © 2018 Turkish Society of Cardiology http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Investigation
Topal, İsmail
Bilgin, Aslı Özbek
Çimen, Ferda Keskin
Kurt, Nezahat
Süleyman, Zeynep
Bilgin, Yasin
Özçiçek, Adalet
Altuner, Durdu
The effect of rutin on cisplatin-induced oxidative cardiac damage in rats
title The effect of rutin on cisplatin-induced oxidative cardiac damage in rats
title_full The effect of rutin on cisplatin-induced oxidative cardiac damage in rats
title_fullStr The effect of rutin on cisplatin-induced oxidative cardiac damage in rats
title_full_unstemmed The effect of rutin on cisplatin-induced oxidative cardiac damage in rats
title_short The effect of rutin on cisplatin-induced oxidative cardiac damage in rats
title_sort effect of rutin on cisplatin-induced oxidative cardiac damage in rats
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237943/
https://www.ncbi.nlm.nih.gov/pubmed/30152807
http://dx.doi.org/10.14744/AnatolJCardiol.2018.32708
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