Association between caspase recruitment domain-containing protein 8 rs2043211 polymorphism and cardiovascular disease susceptibility: A systematic review and meta-analysis

OBJECTIVE: To verify the association between the caspase recruitment domain-containing protein 8 (CARD8) single nucleotide polymorphism rs2043211 in the CARD8 gene and cardiovascular diseases. METHODS: A comprehensive search was conducted for related literature in the PubMed, Embase, Cochrane Library, Web of Science, Wanfang Data, and China National Knowledge Infrastructure databases. At last, Six eligible case-control studies were included in this meta-analysis. Crude odds ratios (ORs) and 95% confidence intervals (CI) were calculated to estimate the strength of the association between CARD8 rs2043211 polymorphisms and the susceptibility of cardiovascular diseases. RESULTS: For the homozygous model, OR was 1.21 (1.08-1.36, I(2)=0.0%, P(heterogeneity)=0.542). For the heterozygous model (AT vs. AA), OR was 1.20 (1.04–1.38, I(2)=57.2%, P(heterogeneity)=0.039). For the dominant model, OR was 1.24 (1.14-1.34, I2=38.5%, P(heterogeneity)=0.149). For the allele model, OR was 0.96 (0.77-1.20, I(2)=92.7%, P(heterogeneity)=0.000). For the recessive model, OR was 1.00 (0.91-1.10, I(2)=48.4%, P(heterogeneity)=0.085). CONCLUSION: The present study showed that CARD8 rs2043211 polymorphism is associated with cardiovascular diseases.