Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine

Adipocytes are the prevalent stromal cell type in adult bone marrow (BM), and leukemia cells continuously adapt to deficiency of nutrients acquiring chemoresistant profiles in the BM microenvironment. We have previously shown that fatty acid metabolism is a key energy pathway for survival of acute m...

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Detalles Bibliográficos
Autores principales: Tabe, Yoko, Saitoh, Kaori, Yang, Haeun, Sekihara, Kazumasa, Yamatani, Kotoko, Ruvolo, Vivian, Taka, Hikari, Kaga, Naoko, Kikkawa, Mika, Arai, Hajime, Miida, Takashi, Andreeff, Michael, Spagnuolo, Paul A., Konopleva, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237992/
https://www.ncbi.nlm.nih.gov/pubmed/30442990
http://dx.doi.org/10.1038/s41598-018-35198-6

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