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Targeting fidelity of adenine and cytosine base editors in mouse embryos

Base editing directly converts a target base pair into a different base pair in the genome of living cells without introducing double-stranded DNA breaks. While cytosine base editors (CBE) and adenine base editors (ABE) are used to install and correct point mutations in a wide range of organisms, th...

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Detalles Bibliográficos
Autores principales:	Lee, Hye Kyung, Willi, Michaela, Miller, Shannon M., Kim, Sojung, Liu, Chengyu, Liu, David R., Hennighausen, Lothar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238002/ https://www.ncbi.nlm.nih.gov/pubmed/30442934 http://dx.doi.org/10.1038/s41467-018-07322-7

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