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Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study

BACKGROUND: Plasmodium vivax malaria is characterized by relapses arising from the hypnozoite stages in the liver. The only currently registered drug for radical treatment to prevent relapse is primaquine. Primaquine, a prodrug, requires metabolism through the liver cytochrome CYP2D6 isoenzyme to it...

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Detalles Bibliográficos
Autores principales:	Puaprasert, Kanokpich, Chu, Cindy, Saralamba, Naowarat, Day, Nicholas P. J., Nosten, Francois, White, Nicholas J., Dondorp, Arjen M., Imwong, Mallika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238304/ https://www.ncbi.nlm.nih.gov/pubmed/30442143 http://dx.doi.org/10.1186/s12936-018-2579-8

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