Cargando…
Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol
BACKGROUND: Momordica charantia Linnaeus (Cucurbitaceae) has been used traditionally as a nutritious food and as a herbal medicine for type 2 diabetes mellitus. However, human studies that investigated its glycemic control have generated inconsistent findings. Therefore, this systematic review and m...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238397/ https://www.ncbi.nlm.nih.gov/pubmed/30442186 http://dx.doi.org/10.1186/s13643-018-0847-x |
_version_ | 1783371370374103040 |
---|---|
author | Peter, Emanuel L. Deyno, Serawit Mtewa, Andrew Kasali, Félicien Mushagalusa Nagendrappa, Prakash B. Sesaazi, Duncan Tolo, Casim Umba Ogwang, Patrick Engeu |
author_facet | Peter, Emanuel L. Deyno, Serawit Mtewa, Andrew Kasali, Félicien Mushagalusa Nagendrappa, Prakash B. Sesaazi, Duncan Tolo, Casim Umba Ogwang, Patrick Engeu |
author_sort | Peter, Emanuel L. |
collection | PubMed |
description | BACKGROUND: Momordica charantia Linnaeus (Cucurbitaceae) has been used traditionally as a nutritious food and as a herbal medicine for type 2 diabetes mellitus. However, human studies that investigated its glycemic control have generated inconsistent findings. Therefore, this systematic review and meta-analysis is aimed at evaluating the safety and efficacy of M. charantia L. preparations in human studies that have investigated its role in glycemic control. METHODS: This protocol has been prepared according to Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The review will include randomized clinical trials and non-randomized clinical trials. The included studies will have assessed glycemic control of M. charantia preparations with placebo or standard oral anti-hyperglycemic agents in adult pre-diabetes and/or type 2 diabetes mellitus patients and have at least 4 weeks of follow-up. The primary outcomes of review are fasting blood glucose levels, glycosylated hemoglobin A1c, and post-prandial blood glucose level. Electronic database search for published literatures will be conducted without language restriction in EMBASE, MEDLINE/PubMed, the Cochrane Library, SCOPUS, Web of Sciences, and CINAHL databases. Search for gray literatures and references of the retrieved full-text articles will be conducted in Google, Google Scholar, OpenGrey, ProQuest dissertations & Theses, British Library EThos, and university digital library systems. Two independent reviewers will later evaluate full texts, extract data, and assess risk of bias of eligible articles. Publication biases will be assessed by testing asymmetry of funnel plot using Egger’s or Begg’s tests while heterogeneity will be assessed using Cochran Q test, P value, and I(2). Revman software version 5.3 will be used for meta-analysis including subgroup and sensitivity analysis. DISCUSSION: This systematic review and meta-analysis will investigate both safety and efficacy of M. charantia preparations in type 2 diabetes mellitus. The review results will be published in a peer-reviewed journal. The results will bring better understanding of clinical outcomes in treatment of type 2 diabetes mellitus patients and highlight gaps for future research. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42018083653. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13643-018-0847-x) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6238397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62383972018-11-26 Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol Peter, Emanuel L. Deyno, Serawit Mtewa, Andrew Kasali, Félicien Mushagalusa Nagendrappa, Prakash B. Sesaazi, Duncan Tolo, Casim Umba Ogwang, Patrick Engeu Syst Rev Protocol BACKGROUND: Momordica charantia Linnaeus (Cucurbitaceae) has been used traditionally as a nutritious food and as a herbal medicine for type 2 diabetes mellitus. However, human studies that investigated its glycemic control have generated inconsistent findings. Therefore, this systematic review and meta-analysis is aimed at evaluating the safety and efficacy of M. charantia L. preparations in human studies that have investigated its role in glycemic control. METHODS: This protocol has been prepared according to Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The review will include randomized clinical trials and non-randomized clinical trials. The included studies will have assessed glycemic control of M. charantia preparations with placebo or standard oral anti-hyperglycemic agents in adult pre-diabetes and/or type 2 diabetes mellitus patients and have at least 4 weeks of follow-up. The primary outcomes of review are fasting blood glucose levels, glycosylated hemoglobin A1c, and post-prandial blood glucose level. Electronic database search for published literatures will be conducted without language restriction in EMBASE, MEDLINE/PubMed, the Cochrane Library, SCOPUS, Web of Sciences, and CINAHL databases. Search for gray literatures and references of the retrieved full-text articles will be conducted in Google, Google Scholar, OpenGrey, ProQuest dissertations & Theses, British Library EThos, and university digital library systems. Two independent reviewers will later evaluate full texts, extract data, and assess risk of bias of eligible articles. Publication biases will be assessed by testing asymmetry of funnel plot using Egger’s or Begg’s tests while heterogeneity will be assessed using Cochran Q test, P value, and I(2). Revman software version 5.3 will be used for meta-analysis including subgroup and sensitivity analysis. DISCUSSION: This systematic review and meta-analysis will investigate both safety and efficacy of M. charantia preparations in type 2 diabetes mellitus. The review results will be published in a peer-reviewed journal. The results will bring better understanding of clinical outcomes in treatment of type 2 diabetes mellitus patients and highlight gaps for future research. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42018083653. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13643-018-0847-x) contains supplementary material, which is available to authorized users. BioMed Central 2018-11-15 /pmc/articles/PMC6238397/ /pubmed/30442186 http://dx.doi.org/10.1186/s13643-018-0847-x Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Protocol Peter, Emanuel L. Deyno, Serawit Mtewa, Andrew Kasali, Félicien Mushagalusa Nagendrappa, Prakash B. Sesaazi, Duncan Tolo, Casim Umba Ogwang, Patrick Engeu Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol |
title | Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol |
title_full | Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol |
title_fullStr | Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol |
title_full_unstemmed | Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol |
title_short | Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol |
title_sort | safety and efficacy of momordica charantia linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol |
topic | Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238397/ https://www.ncbi.nlm.nih.gov/pubmed/30442186 http://dx.doi.org/10.1186/s13643-018-0847-x |
work_keys_str_mv | AT peteremanuell safetyandefficacyofmomordicacharantialinnaeusinprediabetesandtype2diabetesmellituspatientsasystematicreviewandmetaanalysisprotocol AT deynoserawit safetyandefficacyofmomordicacharantialinnaeusinprediabetesandtype2diabetesmellituspatientsasystematicreviewandmetaanalysisprotocol AT mtewaandrew safetyandefficacyofmomordicacharantialinnaeusinprediabetesandtype2diabetesmellituspatientsasystematicreviewandmetaanalysisprotocol AT kasalifelicienmushagalusa safetyandefficacyofmomordicacharantialinnaeusinprediabetesandtype2diabetesmellituspatientsasystematicreviewandmetaanalysisprotocol AT nagendrappaprakashb safetyandefficacyofmomordicacharantialinnaeusinprediabetesandtype2diabetesmellituspatientsasystematicreviewandmetaanalysisprotocol AT sesaaziduncan safetyandefficacyofmomordicacharantialinnaeusinprediabetesandtype2diabetesmellituspatientsasystematicreviewandmetaanalysisprotocol AT tolocasimumba safetyandefficacyofmomordicacharantialinnaeusinprediabetesandtype2diabetesmellituspatientsasystematicreviewandmetaanalysisprotocol AT ogwangpatrickengeu safetyandefficacyofmomordicacharantialinnaeusinprediabetesandtype2diabetesmellituspatientsasystematicreviewandmetaanalysisprotocol |