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Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

New antitubercular agents are needed to combat the spread of multidrug- and extensively drug-resistant strains of Mycobacterium tuberculosis. The frontline antitubercular drug isoniazid (INH) targets the mycobacterial enoyl-ACP reductase, InhA. Resistance to INH is predominantly through mutations af...

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Detalles Bibliográficos
Autores principales:	Xia, Yi, Zhou, Yasheen, Carter, David S, McNeil, Matthew B, Choi, Wai, Halladay, Jason, Berry, Pamela W, Mao, Weimin, Hernandez, Vincent, O'Malley, Theresa, Korkegian, Aaron, Sunde, Bjorn, Flint, Lindsay, Woolhiser, Lisa K, Scherman, Michael S, Gruppo, Veronica, Hastings, Courtney, Robertson, Gregory T, Ioerger, Thomas R, Sacchettini, Jim, Tonge, Peter J, Lenaerts, Anne J, Parish, Tanya, Alley, MRK
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238539/ https://www.ncbi.nlm.nih.gov/pubmed/30456352 http://dx.doi.org/10.26508/lsa.201800025

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