Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity

Like other tumors, aggressive soft tissue sarcomas (STS) use glycolysis rather than mitochondrial oxidative phosphorylation (OXPHOS) for growth. Given the importance of the cofactor coenzyme A (CoA) in energy metabolism, we investigated the impact of Vnn1 pantetheinase—an enzyme that degrades pantet...

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Detalles Bibliográficos
Autores principales: Giessner, Caroline, Millet, Virginie, Mostert, Konrad J, Gensollen, Thomas, Vu Manh, Thien-Phong, Garibal, Marc, Dieme, Binta, Attaf-Bouabdallah, Noudjoud, Chasson, Lionel, Brouilly, Nicolas, Laprie, Caroline, Lesluyes, Tom, Blay, Jean Yves, Shintu, Laetitia, Martin, Jean Charles, Strauss, Erick, Galland, Franck, Naquet, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238586/
https://www.ncbi.nlm.nih.gov/pubmed/30456364
http://dx.doi.org/10.26508/lsa.201800073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238586/
https://www.ncbi.nlm.nih.gov/pubmed/30456364
http://dx.doi.org/10.26508/lsa.201800073

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