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Investigation of multidrug-resistant fatal colisepticaemia in weanling pigs

Escherichia coli is usually a benign commensal of the gut microflora. However, when E. coli acquires virulence genes it can multiply rapidly and cause disease through colonisation of the intestinal mucosa. Escherichia coli can become a significant pathogen in young pigs. We report an investigation o...

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Autores principales: Fasina, Folorunso O., Bwala, Dauda G., Madoroba, Evelyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS OpenJournals 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238774/
https://www.ncbi.nlm.nih.gov/pubmed/26842367
http://dx.doi.org/10.4102/ojvr.v82i1.986
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author Fasina, Folorunso O.
Bwala, Dauda G.
Madoroba, Evelyn
author_facet Fasina, Folorunso O.
Bwala, Dauda G.
Madoroba, Evelyn
author_sort Fasina, Folorunso O.
collection PubMed
description Escherichia coli is usually a benign commensal of the gut microflora. However, when E. coli acquires virulence genes it can multiply rapidly and cause disease through colonisation of the intestinal mucosa. Escherichia coli can become a significant pathogen in young pigs. We report an investigation of fatal colisepticaemia in weanling pigs from emerging farms where piglets and weaners were diarrhoeic and the mortality rate ranged between 15% and 70% in each litter. Faecal and tissue samples were processed for histopathology, bacteriology and molecular biology (multiplex and monoplex polymerase chain reaction) and we recovered enteroaggregative multidrug-resistant E. coli producing EAST-1 enterotoxin. An association between poor housing conditions and the observed cases was established and future management programmes were recommended to reduce the impact of such pathogens. Enteroaggregative E. coli is becoming a major problem in the pig industry. It therefore becomes necessary to establish the full impact of E. coli on the South African pig industry and to determine the geographic extent of the problem.
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spelling pubmed-62387742018-11-26 Investigation of multidrug-resistant fatal colisepticaemia in weanling pigs Fasina, Folorunso O. Bwala, Dauda G. Madoroba, Evelyn Onderstepoort J Vet Res Research Communication Escherichia coli is usually a benign commensal of the gut microflora. However, when E. coli acquires virulence genes it can multiply rapidly and cause disease through colonisation of the intestinal mucosa. Escherichia coli can become a significant pathogen in young pigs. We report an investigation of fatal colisepticaemia in weanling pigs from emerging farms where piglets and weaners were diarrhoeic and the mortality rate ranged between 15% and 70% in each litter. Faecal and tissue samples were processed for histopathology, bacteriology and molecular biology (multiplex and monoplex polymerase chain reaction) and we recovered enteroaggregative multidrug-resistant E. coli producing EAST-1 enterotoxin. An association between poor housing conditions and the observed cases was established and future management programmes were recommended to reduce the impact of such pathogens. Enteroaggregative E. coli is becoming a major problem in the pig industry. It therefore becomes necessary to establish the full impact of E. coli on the South African pig industry and to determine the geographic extent of the problem. AOSIS OpenJournals 2015-11-27 /pmc/articles/PMC6238774/ /pubmed/26842367 http://dx.doi.org/10.4102/ojvr.v82i1.986 Text en © 2015. The Authors http://creativecommons.org/licenses/by/2.0/ Licensee: AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License.
spellingShingle Research Communication
Fasina, Folorunso O.
Bwala, Dauda G.
Madoroba, Evelyn
Investigation of multidrug-resistant fatal colisepticaemia in weanling pigs
title Investigation of multidrug-resistant fatal colisepticaemia in weanling pigs
title_full Investigation of multidrug-resistant fatal colisepticaemia in weanling pigs
title_fullStr Investigation of multidrug-resistant fatal colisepticaemia in weanling pigs
title_full_unstemmed Investigation of multidrug-resistant fatal colisepticaemia in weanling pigs
title_short Investigation of multidrug-resistant fatal colisepticaemia in weanling pigs
title_sort investigation of multidrug-resistant fatal colisepticaemia in weanling pigs
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238774/
https://www.ncbi.nlm.nih.gov/pubmed/26842367
http://dx.doi.org/10.4102/ojvr.v82i1.986
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