Exploring intermediate cell states through the lens of single cells

As our catalog of cell states expands, appropriate characterization of these states and the transitions between them is crucial. Here we discuss the roles of intermediate cell states (ICSs) in this growing collection. We begin with definitions and discuss evidence for the existence of ICSs and their...

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Autores principales: MacLean, Adam L., Hong, Tian, Nie, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238957/
https://www.ncbi.nlm.nih.gov/pubmed/30450444
http://dx.doi.org/10.1016/j.coisb.2018.02.009
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author MacLean, Adam L.
Hong, Tian
Nie, Qing
author_facet MacLean, Adam L.
Hong, Tian
Nie, Qing
author_sort MacLean, Adam L.
collection PubMed
description As our catalog of cell states expands, appropriate characterization of these states and the transitions between them is crucial. Here we discuss the roles of intermediate cell states (ICSs) in this growing collection. We begin with definitions and discuss evidence for the existence of ICSs and their relevance in various tissues. We then provide a list of possible functions for ICSs with examples. Finally, we describe means by which ICSs and their functional roles can be identified from single-cell data or predicted from models.
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spelling pubmed-62389572018-11-16 Exploring intermediate cell states through the lens of single cells MacLean, Adam L. Hong, Tian Nie, Qing Curr Opin Syst Biol Article As our catalog of cell states expands, appropriate characterization of these states and the transitions between them is crucial. Here we discuss the roles of intermediate cell states (ICSs) in this growing collection. We begin with definitions and discuss evidence for the existence of ICSs and their relevance in various tissues. We then provide a list of possible functions for ICSs with examples. Finally, we describe means by which ICSs and their functional roles can be identified from single-cell data or predicted from models. 2018-03-02 2018-06 /pmc/articles/PMC6238957/ /pubmed/30450444 http://dx.doi.org/10.1016/j.coisb.2018.02.009 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
MacLean, Adam L.
Hong, Tian
Nie, Qing
Exploring intermediate cell states through the lens of single cells
title Exploring intermediate cell states through the lens of single cells
title_full Exploring intermediate cell states through the lens of single cells
title_fullStr Exploring intermediate cell states through the lens of single cells
title_full_unstemmed Exploring intermediate cell states through the lens of single cells
title_short Exploring intermediate cell states through the lens of single cells
title_sort exploring intermediate cell states through the lens of single cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238957/
https://www.ncbi.nlm.nih.gov/pubmed/30450444
http://dx.doi.org/10.1016/j.coisb.2018.02.009
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