Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression

TGFβ promotes podocyte hypertrophy and expression of matrix proteins in fibrotic kidney diseases such as diabetic nephropathy. Both mTORC1 and mTORC2 are hyperactive in response to TGFβ in various renal diseases. Deptor is a component of mTOR complexes and a constitutive inhibitor of their activitie...

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Detalles Bibliográficos
Autores principales: Das, Falguni, Ghosh-Choudhury, Nandini, Lee, Doug Yoon, Gorin, Yves, Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239304/
https://www.ncbi.nlm.nih.gov/pubmed/30444896
http://dx.doi.org/10.1371/journal.pone.0207285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239304/
https://www.ncbi.nlm.nih.gov/pubmed/30444896
http://dx.doi.org/10.1371/journal.pone.0207285

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