Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations

Adenosine deaminase (ADA) catalyzes the deamination of adenosine, which is important in purine metabolism. ADA is ubiquitous to almost all human tissues, and ADA abnormalities have been reported in various diseases, including rheumatoid arthritis. ADA can be divided into two conformations based on t...

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Detalles Bibliográficos
Autores principales: Tian, Xiaopian, Liu, Ye, Zhu, Jingxuan, Yu, Zhengfei, Han, Jiarui, Wang, Yan, Han, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239307/
https://www.ncbi.nlm.nih.gov/pubmed/30444912
http://dx.doi.org/10.1371/journal.pone.0207234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239307/
https://www.ncbi.nlm.nih.gov/pubmed/30444912
http://dx.doi.org/10.1371/journal.pone.0207234

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