Induction of N-Ras degradation by flunarizine-mediated autophagy

Ras GTPases are powerful drivers for tumorigenesis, but directly targeting Ras for treating cancer remains challenging. The growth and transforming activity of the aggressive basal-like breast cancer (BLBC) are driven by N-Ras. To target N-Ras in BLBC, this study screened existing pharmacologically...

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Detalles Bibliográficos
Autores principales: Zheng, Ze-Yi, Li, Jing, Li, Fuhai, Zhu, Yanqiao, Cui, Kemi, Wong, Stephen T., Chang, Eric C., Liao, Yi-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240051/
https://www.ncbi.nlm.nih.gov/pubmed/30446677
http://dx.doi.org/10.1038/s41598-018-35237-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240051/
https://www.ncbi.nlm.nih.gov/pubmed/30446677
http://dx.doi.org/10.1038/s41598-018-35237-2

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