Cellular metabolism constrains innate immune responses in early human ontogeny

Pathogen immune responses are profoundly attenuated in fetuses and premature infants, yet the mechanisms underlying this developmental immaturity remain unclear. Here we show transcriptomic, metabolic and polysome profiling and find that monocytes isolated from infants born early in gestation displa...

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Detalles Bibliográficos
Autores principales: Kan, Bernard, Michalski, Christina, Fu, Helen, Au, Hilda H. T., Lee, Kelsey, Marchant, Elizabeth A., Cheng, Maye F., Anderson-Baucum, Emily, Aharoni-Simon, Michal, Tilley, Peter, Mirmira, Raghavendra G., Ross, Colin J., Luciani, Dan S., Jan, Eric, Lavoie, Pascal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240060/
https://www.ncbi.nlm.nih.gov/pubmed/30446641
http://dx.doi.org/10.1038/s41467-018-07215-9

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