Optogenetic dissection of Rac1 and Cdc42 gradient shaping

During cell migration, Rho GTPases spontaneously form spatial gradients that define the front and back of cells. At the front, active Cdc42 forms a steep gradient whereas active Rac1 forms a more extended pattern peaking a few microns away. What are the mechanisms shaping these gradients, and what i...

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Detalles Bibliográficos
Autores principales: de Beco, S., Vaidžiulytė, K., Manzi, J., Dalier, F., di Federico, F., Cornilleau, G., Dahan, M., Coppey, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240110/
https://www.ncbi.nlm.nih.gov/pubmed/30446664
http://dx.doi.org/10.1038/s41467-018-07286-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240110/
https://www.ncbi.nlm.nih.gov/pubmed/30446664
http://dx.doi.org/10.1038/s41467-018-07286-8

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