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Optogenetic dissection of Rac1 and Cdc42 gradient shaping
During cell migration, Rho GTPases spontaneously form spatial gradients that define the front and back of cells. At the front, active Cdc42 forms a steep gradient whereas active Rac1 forms a more extended pattern peaking a few microns away. What are the mechanisms shaping these gradients, and what i...
Autores principales: | de Beco, S., Vaidžiulytė, K., Manzi, J., Dalier, F., di Federico, F., Cornilleau, G., Dahan, M., Coppey, M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240110/ https://www.ncbi.nlm.nih.gov/pubmed/30446664 http://dx.doi.org/10.1038/s41467-018-07286-8 |
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