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Serum vitamin D deficiency in children and adolescents is associated with type 1 diabetes mellitus
BACKGROUND: To investigate the relationship 25-hydroxy vitamin D (25OHD) level among children and in children with type 1 diabetes mellitus (T1DM). METHODS: A case–control study was conducted to compare the serum 25OHD levels between cases and controls. This study recruited 296 T1DM children (106 ne...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bioscientifica Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240138/ https://www.ncbi.nlm.nih.gov/pubmed/30352405 http://dx.doi.org/10.1530/EC-18-0191 |
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author | Liu, Changwei Wang, Jingwen Wan, Yuanyuan Xia, Xiaona Pan, Jian Gu, Wei Li, Mei |
author_facet | Liu, Changwei Wang, Jingwen Wan, Yuanyuan Xia, Xiaona Pan, Jian Gu, Wei Li, Mei |
author_sort | Liu, Changwei |
collection | PubMed |
description | BACKGROUND: To investigate the relationship 25-hydroxy vitamin D (25OHD) level among children and in children with type 1 diabetes mellitus (T1DM). METHODS: A case–control study was conducted to compare the serum 25OHD levels between cases and controls. This study recruited 296 T1DM children (106 newly diagnosed T1DM patients and 190 established T1DM patients), and 295 age- and gender-matched healthy subjects as controls. RESULTS: The mean serum 25OHD in T1DM children was 48.69 ± 15.26 nmol/L and in the controls was 57.93 ± 19.03 nmol/L. The mean serum 25OHD in T1DM children was lower than that of controls (P < 0.01). The mean serum 25OHD level (50.42 ± 14.74 nmol/L) in the newly diagnosed T1DM children was higher than that (47.70 ± 15.50 nmol/L) in the established T1DM children but the difference was not statistically significant (P = 0.16). HbA1c values were associated with 25OHD levels in established T1DM children (r = 0.264, P < 0.01), and there was no association between 25OHD and HbA1c in newly diagnosed T1DM children (r = 0.164; P > 0.05). CONCLUSION: Vitamin D deficiency is common in T1DM children, and it should be worthy of attention on the lack of vitamin D in established T1DM children. |
format | Online Article Text |
id | pubmed-6240138 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62401382018-11-21 Serum vitamin D deficiency in children and adolescents is associated with type 1 diabetes mellitus Liu, Changwei Wang, Jingwen Wan, Yuanyuan Xia, Xiaona Pan, Jian Gu, Wei Li, Mei Endocr Connect Research BACKGROUND: To investigate the relationship 25-hydroxy vitamin D (25OHD) level among children and in children with type 1 diabetes mellitus (T1DM). METHODS: A case–control study was conducted to compare the serum 25OHD levels between cases and controls. This study recruited 296 T1DM children (106 newly diagnosed T1DM patients and 190 established T1DM patients), and 295 age- and gender-matched healthy subjects as controls. RESULTS: The mean serum 25OHD in T1DM children was 48.69 ± 15.26 nmol/L and in the controls was 57.93 ± 19.03 nmol/L. The mean serum 25OHD in T1DM children was lower than that of controls (P < 0.01). The mean serum 25OHD level (50.42 ± 14.74 nmol/L) in the newly diagnosed T1DM children was higher than that (47.70 ± 15.50 nmol/L) in the established T1DM children but the difference was not statistically significant (P = 0.16). HbA1c values were associated with 25OHD levels in established T1DM children (r = 0.264, P < 0.01), and there was no association between 25OHD and HbA1c in newly diagnosed T1DM children (r = 0.164; P > 0.05). CONCLUSION: Vitamin D deficiency is common in T1DM children, and it should be worthy of attention on the lack of vitamin D in established T1DM children. Bioscientifica Ltd 2018-10-10 /pmc/articles/PMC6240138/ /pubmed/30352405 http://dx.doi.org/10.1530/EC-18-0191 Text en © 2018 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Research Liu, Changwei Wang, Jingwen Wan, Yuanyuan Xia, Xiaona Pan, Jian Gu, Wei Li, Mei Serum vitamin D deficiency in children and adolescents is associated with type 1 diabetes mellitus |
title | Serum vitamin D deficiency in children and adolescents is associated with type 1 diabetes mellitus |
title_full | Serum vitamin D deficiency in children and adolescents is associated with type 1 diabetes mellitus |
title_fullStr | Serum vitamin D deficiency in children and adolescents is associated with type 1 diabetes mellitus |
title_full_unstemmed | Serum vitamin D deficiency in children and adolescents is associated with type 1 diabetes mellitus |
title_short | Serum vitamin D deficiency in children and adolescents is associated with type 1 diabetes mellitus |
title_sort | serum vitamin d deficiency in children and adolescents is associated with type 1 diabetes mellitus |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240138/ https://www.ncbi.nlm.nih.gov/pubmed/30352405 http://dx.doi.org/10.1530/EC-18-0191 |
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