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Case report: two confirmed cases of human Seoul virus infections in Indonesia
BACKGROUND: Seoul virus (SEOV) is a member of hantavirus family, which is transmitted to humans by Rattus rattus and Rattus norvegicus. Diagnosing SEOV infection is difficult because the clinical presentations are often undifferentiated with other viral or bacterial infections and assays to test ant...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240170/ https://www.ncbi.nlm.nih.gov/pubmed/30445913 http://dx.doi.org/10.1186/s12879-018-3482-1 |
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author | Lie, Khie Chen Aziz, Mochamad Helmi Kosasih, Herman Neal, Aaron Halim, Caleb Leonardo Wulan, Wahyu Nawang Karyana, Muhammad Hadi, Usman |
author_facet | Lie, Khie Chen Aziz, Mochamad Helmi Kosasih, Herman Neal, Aaron Halim, Caleb Leonardo Wulan, Wahyu Nawang Karyana, Muhammad Hadi, Usman |
author_sort | Lie, Khie Chen |
collection | PubMed |
description | BACKGROUND: Seoul virus (SEOV) is a member of hantavirus family, which is transmitted to humans by Rattus rattus and Rattus norvegicus. Diagnosing SEOV infection is difficult because the clinical presentations are often undifferentiated with other viral or bacterial infections and assays to test antibodies seroconversion and RNA detection are not available in resource-limited setting like Indonesia. CASE PRESENTATION: We report two confirmed cases of SEOV infection from Indonesia. Here, we illustrate the clinical presentations, hematology and biochemistry profiles, and outcomes of the two cases. Phylogenetic analysis revealed that SEOV sequences have highest homology to isolates obtained from rodents in Indonesia. CONCLUSIONS: This report highlights the importance of considering SEOV infection in febrile patients with lymphopenia, thrombocytopenia, and elevation of liver enzyme despite the absence of hemorrhagic manifestations and renal syndromes. The public health importance of rodent-borne diseases such as SEOV infection urges an integrated epidemiological surveillance both in humans and rodents in Indonesia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12879-018-3482-1) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6240170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62401702018-11-26 Case report: two confirmed cases of human Seoul virus infections in Indonesia Lie, Khie Chen Aziz, Mochamad Helmi Kosasih, Herman Neal, Aaron Halim, Caleb Leonardo Wulan, Wahyu Nawang Karyana, Muhammad Hadi, Usman BMC Infect Dis Case Report BACKGROUND: Seoul virus (SEOV) is a member of hantavirus family, which is transmitted to humans by Rattus rattus and Rattus norvegicus. Diagnosing SEOV infection is difficult because the clinical presentations are often undifferentiated with other viral or bacterial infections and assays to test antibodies seroconversion and RNA detection are not available in resource-limited setting like Indonesia. CASE PRESENTATION: We report two confirmed cases of SEOV infection from Indonesia. Here, we illustrate the clinical presentations, hematology and biochemistry profiles, and outcomes of the two cases. Phylogenetic analysis revealed that SEOV sequences have highest homology to isolates obtained from rodents in Indonesia. CONCLUSIONS: This report highlights the importance of considering SEOV infection in febrile patients with lymphopenia, thrombocytopenia, and elevation of liver enzyme despite the absence of hemorrhagic manifestations and renal syndromes. The public health importance of rodent-borne diseases such as SEOV infection urges an integrated epidemiological surveillance both in humans and rodents in Indonesia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12879-018-3482-1) contains supplementary material, which is available to authorized users. BioMed Central 2018-11-16 /pmc/articles/PMC6240170/ /pubmed/30445913 http://dx.doi.org/10.1186/s12879-018-3482-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Lie, Khie Chen Aziz, Mochamad Helmi Kosasih, Herman Neal, Aaron Halim, Caleb Leonardo Wulan, Wahyu Nawang Karyana, Muhammad Hadi, Usman Case report: two confirmed cases of human Seoul virus infections in Indonesia |
title | Case report: two confirmed cases of human Seoul virus infections in Indonesia |
title_full | Case report: two confirmed cases of human Seoul virus infections in Indonesia |
title_fullStr | Case report: two confirmed cases of human Seoul virus infections in Indonesia |
title_full_unstemmed | Case report: two confirmed cases of human Seoul virus infections in Indonesia |
title_short | Case report: two confirmed cases of human Seoul virus infections in Indonesia |
title_sort | case report: two confirmed cases of human seoul virus infections in indonesia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240170/ https://www.ncbi.nlm.nih.gov/pubmed/30445913 http://dx.doi.org/10.1186/s12879-018-3482-1 |
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