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Akt1 inhibition promotes breast cancer metastasis through EGFR-mediated β-catenin nuclear accumulation

BACKGROUND: Knockdown of Akt1 promotes Epithelial-to-Mesenchymal Transition in breast cancer cells. However, the mechanisms are not completely understood. METHODS: Western blotting, immunofluorescence, luciferase assay, real time PCR, ELISA and Matrigel invasion assay were used to investigate how Ak...

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Detalles Bibliográficos
Autores principales:	Li, Wei, Hou, Jiu-Zhou, Niu, Jie, Xi, Zhuo-Qing, Ma, Chang, Sun, Hua, Wang, Chao-Jie, Fang, Dong, Li, Qin, Xie, Song-Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240210/ https://www.ncbi.nlm.nih.gov/pubmed/30445978 http://dx.doi.org/10.1186/s12964-018-0295-1

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