Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response

BACKGROUND: Despite vaccination and screening measures, anogenital cancer, mainly promoted by HPV16 oncoproteins, still represents the fourth tumor and the second cause of death among women. Cell replication fidelity is the result of the host DNA damage response (DDR). Unlike many DNA viruses that p...

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Detalles Bibliográficos
Autores principales: Squarzanti, Diletta Francesca, Sorrentino, Rita, Landini, Manuela Miriam, Chiesa, Andrea, Pinato, Sabrina, Rocchio, Francesca, Mattii, Martina, Penengo, Lorenza, Azzimonti, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240266/
https://www.ncbi.nlm.nih.gov/pubmed/30445982
http://dx.doi.org/10.1186/s12985-018-1086-4

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