Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1–αvβ5 integrin pathway in TLR4-mediated inflammation and injury

BACKGROUND: High tidal volume ventilation of healthy lungs or exacerbation of existing acute lung injury (ALI) by more moderate mechanical ventilation (MTV) produces ventilator-induced lung injury. It is less clear whether extrapulmonary sepsis sensitizes the lung to MTV. METHODS: We used a two-hit...

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Detalles Bibliográficos
Autores principales: Ding, Xibing, Tong, Yao, Jin, Shuqing, Chen, Zhixia, Li, Tunliang, Billiar, Timothy R., Pitt, Bruce R., Li, Quan, Zhang, Li-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240278/
https://www.ncbi.nlm.nih.gov/pubmed/30445996
http://dx.doi.org/10.1186/s13054-018-2237-0

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