Cargando…
Cerebellar large B-cell lymphoma: a case report
BACKGROUND: Primary central nervous system lymphoma is a rare, malignant non-Hodgkin lymphoma that can arise in the brain, spinal cord, eye, leptomeninges, or cranial nerves. Primary central nervous system lymphoma is rare, accounting for 2–6% of all primary brain neoplasms and 1–2% of all non-Hodgk...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240289/ https://www.ncbi.nlm.nih.gov/pubmed/30446015 http://dx.doi.org/10.1186/s13256-018-1880-z |
_version_ | 1783371615113838592 |
---|---|
author | Ghannam, Malik Mansour, Shaden Jumah, Fareed Berry, Brent Beard, Albertine |
author_facet | Ghannam, Malik Mansour, Shaden Jumah, Fareed Berry, Brent Beard, Albertine |
author_sort | Ghannam, Malik |
collection | PubMed |
description | BACKGROUND: Primary central nervous system lymphoma is a rare, malignant non-Hodgkin lymphoma that can arise in the brain, spinal cord, eye, leptomeninges, or cranial nerves. Primary central nervous system lymphoma is rare, accounting for 2–6% of all primary brain neoplasms and 1–2% of all non-Hodgkin lymphomas, and it usually presents as a solitary lesion. Cerebellar involvement is present in only 9% of cases. We present an unusual case of primary central nervous system lymphoma presenting as multiple lesions in the cerebellum in an immunocompetent host. CASE PRESENTATION: A 71-year-old Caucasian man presented to our hospital with acute onset of dizziness, nausea, vomiting, and gait imbalance. Contrast-enhanced computed tomography revealed three intensely enhancing masses in the right cerebellar hemisphere. Whole-body positron emission tomography and computed tomography failed to demonstrate a primary tumor of origin outside the central nervous system. The patient underwent right suboccipital craniotomy with partial resection of the visible tumor from the right cerebellum. Histopathology revealed diffuse large B-cell lymphoma, non-germinal center type. CONCLUSIONS: Primary central nervous system lymphoma is rare, even more so in the cerebellum. However, the overall incidence of primary central nervous system lymphoma is rising in both immunocompromised and immunocompetent patients. The highly aggressive nature of primary central nervous system lymphoma necessitates timely diagnosis and intervention. In this report, we review the available literature for a better understanding of the pathophysiology and management of primary central nervous system lymphoma. To the best of our knowledge, this is the first reported case of a patient with primary central nervous system lymphoma presenting with multiple masses in the cerebellum. |
format | Online Article Text |
id | pubmed-6240289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62402892018-11-23 Cerebellar large B-cell lymphoma: a case report Ghannam, Malik Mansour, Shaden Jumah, Fareed Berry, Brent Beard, Albertine J Med Case Rep Case Report BACKGROUND: Primary central nervous system lymphoma is a rare, malignant non-Hodgkin lymphoma that can arise in the brain, spinal cord, eye, leptomeninges, or cranial nerves. Primary central nervous system lymphoma is rare, accounting for 2–6% of all primary brain neoplasms and 1–2% of all non-Hodgkin lymphomas, and it usually presents as a solitary lesion. Cerebellar involvement is present in only 9% of cases. We present an unusual case of primary central nervous system lymphoma presenting as multiple lesions in the cerebellum in an immunocompetent host. CASE PRESENTATION: A 71-year-old Caucasian man presented to our hospital with acute onset of dizziness, nausea, vomiting, and gait imbalance. Contrast-enhanced computed tomography revealed three intensely enhancing masses in the right cerebellar hemisphere. Whole-body positron emission tomography and computed tomography failed to demonstrate a primary tumor of origin outside the central nervous system. The patient underwent right suboccipital craniotomy with partial resection of the visible tumor from the right cerebellum. Histopathology revealed diffuse large B-cell lymphoma, non-germinal center type. CONCLUSIONS: Primary central nervous system lymphoma is rare, even more so in the cerebellum. However, the overall incidence of primary central nervous system lymphoma is rising in both immunocompromised and immunocompetent patients. The highly aggressive nature of primary central nervous system lymphoma necessitates timely diagnosis and intervention. In this report, we review the available literature for a better understanding of the pathophysiology and management of primary central nervous system lymphoma. To the best of our knowledge, this is the first reported case of a patient with primary central nervous system lymphoma presenting with multiple masses in the cerebellum. BioMed Central 2018-11-17 /pmc/articles/PMC6240289/ /pubmed/30446015 http://dx.doi.org/10.1186/s13256-018-1880-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Ghannam, Malik Mansour, Shaden Jumah, Fareed Berry, Brent Beard, Albertine Cerebellar large B-cell lymphoma: a case report |
title | Cerebellar large B-cell lymphoma: a case report |
title_full | Cerebellar large B-cell lymphoma: a case report |
title_fullStr | Cerebellar large B-cell lymphoma: a case report |
title_full_unstemmed | Cerebellar large B-cell lymphoma: a case report |
title_short | Cerebellar large B-cell lymphoma: a case report |
title_sort | cerebellar large b-cell lymphoma: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240289/ https://www.ncbi.nlm.nih.gov/pubmed/30446015 http://dx.doi.org/10.1186/s13256-018-1880-z |
work_keys_str_mv | AT ghannammalik cerebellarlargebcelllymphomaacasereport AT mansourshaden cerebellarlargebcelllymphomaacasereport AT jumahfareed cerebellarlargebcelllymphomaacasereport AT berrybrent cerebellarlargebcelllymphomaacasereport AT beardalbertine cerebellarlargebcelllymphomaacasereport |