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The Brain Donation Program in South Korea
PURPOSE: Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia in South Korea since 2016. We have built a nationwide br...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Yonsei University College of Medicine
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240560/ https://www.ncbi.nlm.nih.gov/pubmed/30450854 http://dx.doi.org/10.3349/ymj.2018.59.10.1197 |
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author | Kim, Yeshin Suh, Yeon-Lim Kim, Seung Joo Bae, Moon Hwan Kim, Jae Bum Kim, Yuna Choi, Kyung-Chan Huh, Gi Yeong Kim, Eun-Joo Lee, Jung Seok Kang, Hyun Wook Shim, Sung-Mi Lim, Hyun Joung Koh, Young Ho Kim, Byeong-Chae Lee, Kyung-Hwa Lee, Min-Cheol Lee, Ho-Won Lim, Tae Sung Seeley, William W. Kim, Hee Jin Na, Duk L. Lee, Kyung Hoon Seo, Sang Won |
author_facet | Kim, Yeshin Suh, Yeon-Lim Kim, Seung Joo Bae, Moon Hwan Kim, Jae Bum Kim, Yuna Choi, Kyung-Chan Huh, Gi Yeong Kim, Eun-Joo Lee, Jung Seok Kang, Hyun Wook Shim, Sung-Mi Lim, Hyun Joung Koh, Young Ho Kim, Byeong-Chae Lee, Kyung-Hwa Lee, Min-Cheol Lee, Ho-Won Lim, Tae Sung Seeley, William W. Kim, Hee Jin Na, Duk L. Lee, Kyung Hoon Seo, Sang Won |
author_sort | Kim, Yeshin |
collection | PubMed |
description | PURPOSE: Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia in South Korea since 2016. We have built a nationwide brain bank network and are collecting brain tissues from patients with neurodegenerative diseases. We are aiming to facilitate analyses of clinic-pathological and image-pathological correlations of neurodegenerative disease and to broaden understanding thereof. MATERIALS AND METHODS: We recruited participants through two routes: from memory clinics and the community. As a baseline evaluation, clinical interviews, a neurological examination, laboratory tests, neuropsychological tests, and MRI were undertaken. Some patients also underwent amyloid PET. RESULTS: We recruited 105 participants, 70 from clinics and 35 from the community. Among them, 11 died and were autopsied. The clinical diagnoses of the autopsied patients included four with Alzheimer's disease (AD), two with subcortical vascular dementia, two with non-fluent variant primary progressive aphasia, one with leukoencephalopathy, one with frontotemporal dementia (FTD), and one with Creutzfeldt-Jakob disease (CJD). Five patients underwent amyloid PET: two with AD, one with mixed dementia, one with FTD, and one with CJD. CONCLUSION: The clinical and neuropathological information to be obtained from this cohort in the future will provide a deeper understanding of the neuropathological mechanisms of cognitive impairment in Asia, especially Korea. |
format | Online Article Text |
id | pubmed-6240560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-62405602018-12-01 The Brain Donation Program in South Korea Kim, Yeshin Suh, Yeon-Lim Kim, Seung Joo Bae, Moon Hwan Kim, Jae Bum Kim, Yuna Choi, Kyung-Chan Huh, Gi Yeong Kim, Eun-Joo Lee, Jung Seok Kang, Hyun Wook Shim, Sung-Mi Lim, Hyun Joung Koh, Young Ho Kim, Byeong-Chae Lee, Kyung-Hwa Lee, Min-Cheol Lee, Ho-Won Lim, Tae Sung Seeley, William W. Kim, Hee Jin Na, Duk L. Lee, Kyung Hoon Seo, Sang Won Yonsei Med J Original Article PURPOSE: Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia in South Korea since 2016. We have built a nationwide brain bank network and are collecting brain tissues from patients with neurodegenerative diseases. We are aiming to facilitate analyses of clinic-pathological and image-pathological correlations of neurodegenerative disease and to broaden understanding thereof. MATERIALS AND METHODS: We recruited participants through two routes: from memory clinics and the community. As a baseline evaluation, clinical interviews, a neurological examination, laboratory tests, neuropsychological tests, and MRI were undertaken. Some patients also underwent amyloid PET. RESULTS: We recruited 105 participants, 70 from clinics and 35 from the community. Among them, 11 died and were autopsied. The clinical diagnoses of the autopsied patients included four with Alzheimer's disease (AD), two with subcortical vascular dementia, two with non-fluent variant primary progressive aphasia, one with leukoencephalopathy, one with frontotemporal dementia (FTD), and one with Creutzfeldt-Jakob disease (CJD). Five patients underwent amyloid PET: two with AD, one with mixed dementia, one with FTD, and one with CJD. CONCLUSION: The clinical and neuropathological information to be obtained from this cohort in the future will provide a deeper understanding of the neuropathological mechanisms of cognitive impairment in Asia, especially Korea. Yonsei University College of Medicine 2018-12-01 2018-11-15 /pmc/articles/PMC6240560/ /pubmed/30450854 http://dx.doi.org/10.3349/ymj.2018.59.10.1197 Text en © Copyright: Yonsei University College of Medicine 2018 https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Yeshin Suh, Yeon-Lim Kim, Seung Joo Bae, Moon Hwan Kim, Jae Bum Kim, Yuna Choi, Kyung-Chan Huh, Gi Yeong Kim, Eun-Joo Lee, Jung Seok Kang, Hyun Wook Shim, Sung-Mi Lim, Hyun Joung Koh, Young Ho Kim, Byeong-Chae Lee, Kyung-Hwa Lee, Min-Cheol Lee, Ho-Won Lim, Tae Sung Seeley, William W. Kim, Hee Jin Na, Duk L. Lee, Kyung Hoon Seo, Sang Won The Brain Donation Program in South Korea |
title | The Brain Donation Program in South Korea |
title_full | The Brain Donation Program in South Korea |
title_fullStr | The Brain Donation Program in South Korea |
title_full_unstemmed | The Brain Donation Program in South Korea |
title_short | The Brain Donation Program in South Korea |
title_sort | brain donation program in south korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240560/ https://www.ncbi.nlm.nih.gov/pubmed/30450854 http://dx.doi.org/10.3349/ymj.2018.59.10.1197 |
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