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Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2

A single nucleotide polymorphism, C1858T, in the gene encoding the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) results in one of the strongest genetic traits associated with autoimmune disease outside of the Major Histocompatibility Complex (MHC) genes. However, the consequences of thi...

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Detalles Bibliográficos
Autores principales:	Bray, Cara, Wright, David, Haupt, Sonja, Thomas, Sharyn, Stauss, Hans, Zamoyska, Rose
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240618/ https://www.ncbi.nlm.nih.gov/pubmed/30483260 http://dx.doi.org/10.3389/fimmu.2018.02595

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