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Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?
Metabolic syndrome is accompanied by oxidative stress in animals and humans. The main source of ROS in experimental metabolic syndrome is NADPH oxidase and possibly adipocyte mitochondria. It is now documented that oxidative stress induces insulin resistance of adipocytes and increases secretion of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240632/ https://www.ncbi.nlm.nih.gov/pubmed/30479968 http://dx.doi.org/10.1016/j.jcte.2018.11.001 |
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author | Maslov, Leonid N. Naryzhnaya, Natalia V. Boshchenko, Alla A. Popov, Sergey V. Ivanov, Vladimir V. Oeltgen, Peter R. |
author_facet | Maslov, Leonid N. Naryzhnaya, Natalia V. Boshchenko, Alla A. Popov, Sergey V. Ivanov, Vladimir V. Oeltgen, Peter R. |
author_sort | Maslov, Leonid N. |
collection | PubMed |
description | Metabolic syndrome is accompanied by oxidative stress in animals and humans. The main source of ROS in experimental metabolic syndrome is NADPH oxidase and possibly adipocyte mitochondria. It is now documented that oxidative stress induces insulin resistance of adipocytes and increases secretion of leptin, MCP-1, IL-6, and TNF-α by adipocytes. It was established that oxidative stress induces a decrease in adiponectin production by adipocytes. It has also been shown that obesity itself can induce oxidative stress. Oxidative stress can cause an alteration of intracellular signaling in adipocytes that apparently leads to the formation of insulin resistance of adipocytes. Chronic stress, glucocorticoids, mineralocorticoids, angiotensin-II, TNF-α also play an important role in the pathogenesis of oxidative stress of adipocytes. Oxidative stress is not only a consequence of metabolic syndrome, but also a reason and a foundational link in the pathogenesis of the metabolic syndrome. |
format | Online Article Text |
id | pubmed-6240632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-62406322018-11-26 Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome? Maslov, Leonid N. Naryzhnaya, Natalia V. Boshchenko, Alla A. Popov, Sergey V. Ivanov, Vladimir V. Oeltgen, Peter R. J Clin Transl Endocrinol Review Metabolic syndrome is accompanied by oxidative stress in animals and humans. The main source of ROS in experimental metabolic syndrome is NADPH oxidase and possibly adipocyte mitochondria. It is now documented that oxidative stress induces insulin resistance of adipocytes and increases secretion of leptin, MCP-1, IL-6, and TNF-α by adipocytes. It was established that oxidative stress induces a decrease in adiponectin production by adipocytes. It has also been shown that obesity itself can induce oxidative stress. Oxidative stress can cause an alteration of intracellular signaling in adipocytes that apparently leads to the formation of insulin resistance of adipocytes. Chronic stress, glucocorticoids, mineralocorticoids, angiotensin-II, TNF-α also play an important role in the pathogenesis of oxidative stress of adipocytes. Oxidative stress is not only a consequence of metabolic syndrome, but also a reason and a foundational link in the pathogenesis of the metabolic syndrome. Elsevier 2018-11-09 /pmc/articles/PMC6240632/ /pubmed/30479968 http://dx.doi.org/10.1016/j.jcte.2018.11.001 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Maslov, Leonid N. Naryzhnaya, Natalia V. Boshchenko, Alla A. Popov, Sergey V. Ivanov, Vladimir V. Oeltgen, Peter R. Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome? |
title | Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome? |
title_full | Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome? |
title_fullStr | Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome? |
title_full_unstemmed | Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome? |
title_short | Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome? |
title_sort | is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240632/ https://www.ncbi.nlm.nih.gov/pubmed/30479968 http://dx.doi.org/10.1016/j.jcte.2018.11.001 |
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