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Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?

Metabolic syndrome is accompanied by oxidative stress in animals and humans. The main source of ROS in experimental metabolic syndrome is NADPH oxidase and possibly adipocyte mitochondria. It is now documented that oxidative stress induces insulin resistance of adipocytes and increases secretion of...

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Detalles Bibliográficos
Autores principales: Maslov, Leonid N., Naryzhnaya, Natalia V., Boshchenko, Alla A., Popov, Sergey V., Ivanov, Vladimir V., Oeltgen, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240632/
https://www.ncbi.nlm.nih.gov/pubmed/30479968
http://dx.doi.org/10.1016/j.jcte.2018.11.001
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author Maslov, Leonid N.
Naryzhnaya, Natalia V.
Boshchenko, Alla A.
Popov, Sergey V.
Ivanov, Vladimir V.
Oeltgen, Peter R.
author_facet Maslov, Leonid N.
Naryzhnaya, Natalia V.
Boshchenko, Alla A.
Popov, Sergey V.
Ivanov, Vladimir V.
Oeltgen, Peter R.
author_sort Maslov, Leonid N.
collection PubMed
description Metabolic syndrome is accompanied by oxidative stress in animals and humans. The main source of ROS in experimental metabolic syndrome is NADPH oxidase and possibly adipocyte mitochondria. It is now documented that oxidative stress induces insulin resistance of adipocytes and increases secretion of leptin, MCP-1, IL-6, and TNF-α by adipocytes. It was established that oxidative stress induces a decrease in adiponectin production by adipocytes. It has also been shown that obesity itself can induce oxidative stress. Oxidative stress can cause an alteration of intracellular signaling in adipocytes that apparently leads to the formation of insulin resistance of adipocytes. Chronic stress, glucocorticoids, mineralocorticoids, angiotensin-II, TNF-α also play an important role in the pathogenesis of oxidative stress of adipocytes. Oxidative stress is not only a consequence of metabolic syndrome, but also a reason and a foundational link in the pathogenesis of the metabolic syndrome.
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spelling pubmed-62406322018-11-26 Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome? Maslov, Leonid N. Naryzhnaya, Natalia V. Boshchenko, Alla A. Popov, Sergey V. Ivanov, Vladimir V. Oeltgen, Peter R. J Clin Transl Endocrinol Review Metabolic syndrome is accompanied by oxidative stress in animals and humans. The main source of ROS in experimental metabolic syndrome is NADPH oxidase and possibly adipocyte mitochondria. It is now documented that oxidative stress induces insulin resistance of adipocytes and increases secretion of leptin, MCP-1, IL-6, and TNF-α by adipocytes. It was established that oxidative stress induces a decrease in adiponectin production by adipocytes. It has also been shown that obesity itself can induce oxidative stress. Oxidative stress can cause an alteration of intracellular signaling in adipocytes that apparently leads to the formation of insulin resistance of adipocytes. Chronic stress, glucocorticoids, mineralocorticoids, angiotensin-II, TNF-α also play an important role in the pathogenesis of oxidative stress of adipocytes. Oxidative stress is not only a consequence of metabolic syndrome, but also a reason and a foundational link in the pathogenesis of the metabolic syndrome. Elsevier 2018-11-09 /pmc/articles/PMC6240632/ /pubmed/30479968 http://dx.doi.org/10.1016/j.jcte.2018.11.001 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Maslov, Leonid N.
Naryzhnaya, Natalia V.
Boshchenko, Alla A.
Popov, Sergey V.
Ivanov, Vladimir V.
Oeltgen, Peter R.
Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?
title Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?
title_full Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?
title_fullStr Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?
title_full_unstemmed Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?
title_short Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?
title_sort is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240632/
https://www.ncbi.nlm.nih.gov/pubmed/30479968
http://dx.doi.org/10.1016/j.jcte.2018.11.001
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