NHE8 Deficiency Promotes Colitis-Associated Cancer in Mice via Expansion of Lgr5-Expressing Cells

BACKGROUND & AIMS: Lgr5 overexpression has been detected in colorectal cancers (CRCs), including some cases of colitis-associated CRCs. In colitis-associated CRCs, chronic inflammation is a contributing factor in carcinogenesis. We recently reported that intestinal Na(+)/H(+) exchanger isoform 8...

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Detalles Bibliográficos
Autores principales: Xu, Hua, Li, Jing, Chen, Hao, Ghishan, Fayez K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240644/
https://www.ncbi.nlm.nih.gov/pubmed/30465020
http://dx.doi.org/10.1016/j.jcmgh.2018.08.005

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