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Isotope Tracing Untargeted Metabolomics Reveals Macrophage Polarization-State-Specific Metabolic Coordination across Intracellular Compartments

We apply stable isotope tracing, mass-spectrometry-based untargeted metabolomics, to reveal the biochemical space labeled by (13)C-substrates in bone-marrow-derived macrophages. At the pathway level, classically (lipopolysaccharide [LPS]-polarized, M1) and alternatively (interleukin [IL]-4-polarized...

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Detalles Bibliográficos
Autores principales:	Puchalska, Patrycja, Huang, Xiaojing, Martin, Shannon E., Han, Xianlin, Patti, Gary J., Crawford, Peter A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240706/ https://www.ncbi.nlm.nih.gov/pubmed/30448730 http://dx.doi.org/10.1016/j.isci.2018.10.029

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