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A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4

Double homeobox 4 (DUX4), the causative gene of facioscapulohumeral muscular dystrophy (FSHD), is ectopically expressed in the skeletal muscle cells of FSHD patients because of chromatin relaxation at 4q35. The diminished heterochromatic state at 4q35 is caused by either large genome contractions [F...

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Detalles Bibliográficos
Autores principales:	Sasaki-Honda, Mitsuru, Jonouchi, Tatsuya, Arai, Meni, Hotta, Akitsu, Mitsuhashi, Satomi, Nishino, Ichizo, Matsuda, Ryoichi, Sakurai, Hidetoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240734/ https://www.ncbi.nlm.nih.gov/pubmed/30107443 http://dx.doi.org/10.1093/hmg/ddy293

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