Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis

Activation of hepatic stellate cell (HSC) involves the transition from a quiescent to a proliferative, migratory, and fibrogenic phenotype (i.e., myofibroblast), which is characteristic of liver fibrogenesis. Multiple cellular and molecular signals which contribute to HSC activation have been identi...

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Detalles Bibliográficos
Autores principales: Hou, Wei, Syn, Wing-Kin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240744/
https://www.ncbi.nlm.nih.gov/pubmed/30483502
http://dx.doi.org/10.3389/fcell.2018.00150
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author Hou, Wei
Syn, Wing-Kin
author_facet Hou, Wei
Syn, Wing-Kin
author_sort Hou, Wei
collection PubMed
description Activation of hepatic stellate cell (HSC) involves the transition from a quiescent to a proliferative, migratory, and fibrogenic phenotype (i.e., myofibroblast), which is characteristic of liver fibrogenesis. Multiple cellular and molecular signals which contribute to HSC activation have been identified. This review specially focuses on the metabolic changes which impact on HSC activation and fibrogenesis.
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spelling pubmed-62407442018-11-27 Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis Hou, Wei Syn, Wing-Kin Front Cell Dev Biol Physiology Activation of hepatic stellate cell (HSC) involves the transition from a quiescent to a proliferative, migratory, and fibrogenic phenotype (i.e., myofibroblast), which is characteristic of liver fibrogenesis. Multiple cellular and molecular signals which contribute to HSC activation have been identified. This review specially focuses on the metabolic changes which impact on HSC activation and fibrogenesis. Frontiers Media S.A. 2018-11-12 /pmc/articles/PMC6240744/ /pubmed/30483502 http://dx.doi.org/10.3389/fcell.2018.00150 Text en Copyright © 2018 Hou and Syn. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Hou, Wei
Syn, Wing-Kin
Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis
title Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis
title_full Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis
title_fullStr Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis
title_full_unstemmed Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis
title_short Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis
title_sort role of metabolism in hepatic stellate cell activation and fibrogenesis
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240744/
https://www.ncbi.nlm.nih.gov/pubmed/30483502
http://dx.doi.org/10.3389/fcell.2018.00150
work_keys_str_mv AT houwei roleofmetabolisminhepaticstellatecellactivationandfibrogenesis
AT synwingkin roleofmetabolisminhepaticstellatecellactivationandfibrogenesis

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