New self-assembling peptide nanotubes of large diameter using δ-amino acids

Here we show that 4-aminocyclohexanecarboxylic acid is a rigid stretcher building block for the preparation of cyclic peptides that self-assemble to form peptide nanotubes with large diameter and hydrophobic pores. The hydrophobic properties of the resulting nanotubes provided by the two methylene g...

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Detalles Bibliográficos
Autores principales: Lamas, Alejandro, Guerra, Arcadio, Amorín, Manuel, Granja, Juan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240800/
https://www.ncbi.nlm.nih.gov/pubmed/30542571
http://dx.doi.org/10.1039/c8sc02276c
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author Lamas, Alejandro
Guerra, Arcadio
Amorín, Manuel
Granja, Juan R.
author_facet Lamas, Alejandro
Guerra, Arcadio
Amorín, Manuel
Granja, Juan R.
author_sort Lamas, Alejandro
collection PubMed
description Here we show that 4-aminocyclohexanecarboxylic acid is a rigid stretcher building block for the preparation of cyclic peptides that self-assemble to form peptide nanotubes with large diameter and hydrophobic pores. The hydrophobic properties of the resulting nanotubes provided by the two methylene groups per δ-residue allow the encapsulation of C(60) moieties forming a new type of bionanopeapod structure.
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spelling pubmed-62408002018-12-12 New self-assembling peptide nanotubes of large diameter using δ-amino acids Lamas, Alejandro Guerra, Arcadio Amorín, Manuel Granja, Juan R. Chem Sci Chemistry Here we show that 4-aminocyclohexanecarboxylic acid is a rigid stretcher building block for the preparation of cyclic peptides that self-assemble to form peptide nanotubes with large diameter and hydrophobic pores. The hydrophobic properties of the resulting nanotubes provided by the two methylene groups per δ-residue allow the encapsulation of C(60) moieties forming a new type of bionanopeapod structure. Royal Society of Chemistry 2018-08-27 /pmc/articles/PMC6240800/ /pubmed/30542571 http://dx.doi.org/10.1039/c8sc02276c Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Lamas, Alejandro
Guerra, Arcadio
Amorín, Manuel
Granja, Juan R.
New self-assembling peptide nanotubes of large diameter using δ-amino acids
title New self-assembling peptide nanotubes of large diameter using δ-amino acids
title_full New self-assembling peptide nanotubes of large diameter using δ-amino acids
title_fullStr New self-assembling peptide nanotubes of large diameter using δ-amino acids
title_full_unstemmed New self-assembling peptide nanotubes of large diameter using δ-amino acids
title_short New self-assembling peptide nanotubes of large diameter using δ-amino acids
title_sort new self-assembling peptide nanotubes of large diameter using δ-amino acids
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240800/
https://www.ncbi.nlm.nih.gov/pubmed/30542571
http://dx.doi.org/10.1039/c8sc02276c
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