The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA

Sirtuin 3 (SIRT3) deacetylates and activates several mitochondrial fatty acid oxidation enzymes in the liver. Here, we investigated whether the protein acetylase GCN5 general control of amino acid synthesis 5-like 1 (GCN5L1), previously shown to oppose SIRT3 activity, is involved in the regulation o...

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Detalles Bibliográficos
Autores principales: Thapa, Dharendra, Wu, Kaiyuan, Stoner, Michael W., Xie, Bingxian, Zhang, Manling, Manning, Janet R., Lu, Zhongping, Li, Jian H., Chen, Yong, Gucek, Marjan, Playford, Martin P., Mehta, Nehal N., Harmon, Daniel, O'Doherty, Robert M., Jurczak, Michael J., Sack, Michael N., Scott, Iain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Accelerated Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240879/
https://www.ncbi.nlm.nih.gov/pubmed/30323061
http://dx.doi.org/10.1074/jbc.AC118.005462

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