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Engineering of CYP76AH15 can improve activity and specificity towards forskolin biosynthesis in yeast

BACKGROUND: Forskolin is a high-value diterpenoid produced exclusively by the Lamiaceae plant Coleus forskohlii. Today forskolin is used pharmaceutically for its adenyl-cyclase activating properties. The limited availability of pure forskolin is currently hindering its full utilization, thus a new...

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Detalles Bibliográficos
Autores principales:	Forman, Victor, Bjerg-Jensen, Niels, Dyekjær, Jane D., Møller, Birger Lindberg, Pateraki, Irini
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240942/ https://www.ncbi.nlm.nih.gov/pubmed/30453976 http://dx.doi.org/10.1186/s12934-018-1027-3

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