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Focus on the role of substance P in chronic urticaria

BACKGROUND: Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized. METHODS: Literature data regarding the possible role of SP in chronic urticaria/chronic spontane...

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Autores principales: Vena, Gino A., Cassano, Nicoletta, Di Leo, E., Calogiuri, G. F., Nettis, Eustachio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240950/
https://www.ncbi.nlm.nih.gov/pubmed/30473632
http://dx.doi.org/10.1186/s12948-018-0101-z
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author Vena, Gino A.
Cassano, Nicoletta
Di Leo, E.
Calogiuri, G. F.
Nettis, Eustachio
author_facet Vena, Gino A.
Cassano, Nicoletta
Di Leo, E.
Calogiuri, G. F.
Nettis, Eustachio
author_sort Vena, Gino A.
collection PubMed
description BACKGROUND: Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized. METHODS: Literature data regarding the possible role of SP in chronic urticaria/chronic spontaneous urticaria (CSU) have been reviewed and summarized in this manuscript. This review is based on pertinent articles that were retrieved by a selective literature search in the PubMed database. Articles in English published up to July 2018 were taken into consideration. RESULTS: Recent studies in patients with CSU have demonstrated that circulating levels of SP are significantly elevated, in correlation with disease severity, and that SP-positive basophils are upregulated. SP has been shown to trigger degranulation in basophils derived from CSU patients. Moreover, SP can be involved in pseudoallergic reactions and may act as a histamine-releasing factor in a subset of patients with CSU. Current evidence suggests that the biological activity of SP can be exerted not only through the conventional NK-1 receptor but also through the recently identified Mas-related G protein-coupled receptors. MRGPRX2 can cause mast cell activation and has been found to be upregulated in the skin of patients with severe chronic urticaria. CONCLUSIONS: Many findings seem to support the pathogenic involvement of SP in chronic urticaria/CSU. However, further studies are necessary to elucidate the role of SP as a mediator in CSU pathogenesis and a potential new therapeutic target.
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spelling pubmed-62409502018-11-23 Focus on the role of substance P in chronic urticaria Vena, Gino A. Cassano, Nicoletta Di Leo, E. Calogiuri, G. F. Nettis, Eustachio Clin Mol Allergy Review BACKGROUND: Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized. METHODS: Literature data regarding the possible role of SP in chronic urticaria/chronic spontaneous urticaria (CSU) have been reviewed and summarized in this manuscript. This review is based on pertinent articles that were retrieved by a selective literature search in the PubMed database. Articles in English published up to July 2018 were taken into consideration. RESULTS: Recent studies in patients with CSU have demonstrated that circulating levels of SP are significantly elevated, in correlation with disease severity, and that SP-positive basophils are upregulated. SP has been shown to trigger degranulation in basophils derived from CSU patients. Moreover, SP can be involved in pseudoallergic reactions and may act as a histamine-releasing factor in a subset of patients with CSU. Current evidence suggests that the biological activity of SP can be exerted not only through the conventional NK-1 receptor but also through the recently identified Mas-related G protein-coupled receptors. MRGPRX2 can cause mast cell activation and has been found to be upregulated in the skin of patients with severe chronic urticaria. CONCLUSIONS: Many findings seem to support the pathogenic involvement of SP in chronic urticaria/CSU. However, further studies are necessary to elucidate the role of SP as a mediator in CSU pathogenesis and a potential new therapeutic target. BioMed Central 2018-11-19 /pmc/articles/PMC6240950/ /pubmed/30473632 http://dx.doi.org/10.1186/s12948-018-0101-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Vena, Gino A.
Cassano, Nicoletta
Di Leo, E.
Calogiuri, G. F.
Nettis, Eustachio
Focus on the role of substance P in chronic urticaria
title Focus on the role of substance P in chronic urticaria
title_full Focus on the role of substance P in chronic urticaria
title_fullStr Focus on the role of substance P in chronic urticaria
title_full_unstemmed Focus on the role of substance P in chronic urticaria
title_short Focus on the role of substance P in chronic urticaria
title_sort focus on the role of substance p in chronic urticaria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240950/
https://www.ncbi.nlm.nih.gov/pubmed/30473632
http://dx.doi.org/10.1186/s12948-018-0101-z
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