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Focus on the role of substance P in chronic urticaria
BACKGROUND: Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized. METHODS: Literature data regarding the possible role of SP in chronic urticaria/chronic spontane...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240950/ https://www.ncbi.nlm.nih.gov/pubmed/30473632 http://dx.doi.org/10.1186/s12948-018-0101-z |
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author | Vena, Gino A. Cassano, Nicoletta Di Leo, E. Calogiuri, G. F. Nettis, Eustachio |
author_facet | Vena, Gino A. Cassano, Nicoletta Di Leo, E. Calogiuri, G. F. Nettis, Eustachio |
author_sort | Vena, Gino A. |
collection | PubMed |
description | BACKGROUND: Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized. METHODS: Literature data regarding the possible role of SP in chronic urticaria/chronic spontaneous urticaria (CSU) have been reviewed and summarized in this manuscript. This review is based on pertinent articles that were retrieved by a selective literature search in the PubMed database. Articles in English published up to July 2018 were taken into consideration. RESULTS: Recent studies in patients with CSU have demonstrated that circulating levels of SP are significantly elevated, in correlation with disease severity, and that SP-positive basophils are upregulated. SP has been shown to trigger degranulation in basophils derived from CSU patients. Moreover, SP can be involved in pseudoallergic reactions and may act as a histamine-releasing factor in a subset of patients with CSU. Current evidence suggests that the biological activity of SP can be exerted not only through the conventional NK-1 receptor but also through the recently identified Mas-related G protein-coupled receptors. MRGPRX2 can cause mast cell activation and has been found to be upregulated in the skin of patients with severe chronic urticaria. CONCLUSIONS: Many findings seem to support the pathogenic involvement of SP in chronic urticaria/CSU. However, further studies are necessary to elucidate the role of SP as a mediator in CSU pathogenesis and a potential new therapeutic target. |
format | Online Article Text |
id | pubmed-6240950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62409502018-11-23 Focus on the role of substance P in chronic urticaria Vena, Gino A. Cassano, Nicoletta Di Leo, E. Calogiuri, G. F. Nettis, Eustachio Clin Mol Allergy Review BACKGROUND: Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized. METHODS: Literature data regarding the possible role of SP in chronic urticaria/chronic spontaneous urticaria (CSU) have been reviewed and summarized in this manuscript. This review is based on pertinent articles that were retrieved by a selective literature search in the PubMed database. Articles in English published up to July 2018 were taken into consideration. RESULTS: Recent studies in patients with CSU have demonstrated that circulating levels of SP are significantly elevated, in correlation with disease severity, and that SP-positive basophils are upregulated. SP has been shown to trigger degranulation in basophils derived from CSU patients. Moreover, SP can be involved in pseudoallergic reactions and may act as a histamine-releasing factor in a subset of patients with CSU. Current evidence suggests that the biological activity of SP can be exerted not only through the conventional NK-1 receptor but also through the recently identified Mas-related G protein-coupled receptors. MRGPRX2 can cause mast cell activation and has been found to be upregulated in the skin of patients with severe chronic urticaria. CONCLUSIONS: Many findings seem to support the pathogenic involvement of SP in chronic urticaria/CSU. However, further studies are necessary to elucidate the role of SP as a mediator in CSU pathogenesis and a potential new therapeutic target. BioMed Central 2018-11-19 /pmc/articles/PMC6240950/ /pubmed/30473632 http://dx.doi.org/10.1186/s12948-018-0101-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Vena, Gino A. Cassano, Nicoletta Di Leo, E. Calogiuri, G. F. Nettis, Eustachio Focus on the role of substance P in chronic urticaria |
title | Focus on the role of substance P in chronic urticaria |
title_full | Focus on the role of substance P in chronic urticaria |
title_fullStr | Focus on the role of substance P in chronic urticaria |
title_full_unstemmed | Focus on the role of substance P in chronic urticaria |
title_short | Focus on the role of substance P in chronic urticaria |
title_sort | focus on the role of substance p in chronic urticaria |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240950/ https://www.ncbi.nlm.nih.gov/pubmed/30473632 http://dx.doi.org/10.1186/s12948-018-0101-z |
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