Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment

The experiment was carried out on 120 female white Wistar rats, to study the endothelio- and osteoprotective action of the combination of rosuvastatin with L-norvaline in the model of experimental osteoporosis. It was found that, after ovariectomy in rats, endothelial dysfunction of the vessels of t...

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Autores principales: Sobolev, M. S., Faitelson, A. V., Gudyrev, O. S., Rajkumar, D. S. R., Dubrovin, G. M., Anikanov, A. V., Koklina, N. U., Chernomortseva, E. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241240/
https://www.ncbi.nlm.nih.gov/pubmed/30519391
http://dx.doi.org/10.1155/2018/1585749
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author Sobolev, M. S.
Faitelson, A. V.
Gudyrev, O. S.
Rajkumar, D. S. R.
Dubrovin, G. M.
Anikanov, A. V.
Koklina, N. U.
Chernomortseva, E. S.
author_facet Sobolev, M. S.
Faitelson, A. V.
Gudyrev, O. S.
Rajkumar, D. S. R.
Dubrovin, G. M.
Anikanov, A. V.
Koklina, N. U.
Chernomortseva, E. S.
author_sort Sobolev, M. S.
collection PubMed
description The experiment was carried out on 120 female white Wistar rats, to study the endothelio- and osteoprotective action of the combination of rosuvastatin with L-norvaline in the model of experimental osteoporosis. It was found that, after ovariectomy in rats, endothelial dysfunction of the vessels of the microcirculatory bed of bone tissue develops, leading to the appearance of osteoporosis, but the combination of the studied drugs prevents the decrease in the level of microcirculation in the bone tissue, thereby preventing the thinning of bone trabeculae and preventing the occurrence of microfractures in them.
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spelling pubmed-62412402018-12-05 Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment Sobolev, M. S. Faitelson, A. V. Gudyrev, O. S. Rajkumar, D. S. R. Dubrovin, G. M. Anikanov, A. V. Koklina, N. U. Chernomortseva, E. S. J Osteoporos Research Article The experiment was carried out on 120 female white Wistar rats, to study the endothelio- and osteoprotective action of the combination of rosuvastatin with L-norvaline in the model of experimental osteoporosis. It was found that, after ovariectomy in rats, endothelial dysfunction of the vessels of the microcirculatory bed of bone tissue develops, leading to the appearance of osteoporosis, but the combination of the studied drugs prevents the decrease in the level of microcirculation in the bone tissue, thereby preventing the thinning of bone trabeculae and preventing the occurrence of microfractures in them. Hindawi 2018-11-05 /pmc/articles/PMC6241240/ /pubmed/30519391 http://dx.doi.org/10.1155/2018/1585749 Text en Copyright © 2018 M. S. Sobolev et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sobolev, M. S.
Faitelson, A. V.
Gudyrev, O. S.
Rajkumar, D. S. R.
Dubrovin, G. M.
Anikanov, A. V.
Koklina, N. U.
Chernomortseva, E. S.
Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment
title Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment
title_full Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment
title_fullStr Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment
title_full_unstemmed Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment
title_short Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment
title_sort study of endothelio- and osteoprotective effects of combination of rosuvastatin with l-norvaline in experiment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241240/
https://www.ncbi.nlm.nih.gov/pubmed/30519391
http://dx.doi.org/10.1155/2018/1585749
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