A Novel Oncolytic Herpes Simplex Virus Design based on the Common Overexpression of microRNA-21 in Tumors

BACKGROUND: Recognition sequences for microRNAs (miRs) that are down-regulated in tumor cells have recently been used to render lytic viruses tumor-specific. Since different tumor types down-regulate different miRs, this strategy requires virus customization to the target tumor. We have explored a f...

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Detalles Bibliográficos
Autores principales: Marzulli, M, Mazzacurati, L, Zhang, M, Goins, WF, Hatley, ME, Glorioso, JC, Cohen, JB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241327/
https://www.ncbi.nlm.nih.gov/pubmed/30465046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241327/
https://www.ncbi.nlm.nih.gov/pubmed/30465046

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