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Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report

Suspected urinary tract infection is a common indication for antimicrobial therapy in long-term care residents. We sought to characterize antimicrobial susceptibilities among urine isolates collected from women long-term care residents enrolled in a clinical trial across 21 long-term care facilities...

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Autores principales: Datta, Rupak, Advani, Sonali, Rink, Andrea, Bianco, Luann, Van Ness, Peter H, Quagliarello, Vincent, Juthani-Mehta, Manisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241532/
https://www.ncbi.nlm.nih.gov/pubmed/30465048
http://dx.doi.org/10.19080/OAJGGM.2018.04.555636
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author Datta, Rupak
Advani, Sonali
Rink, Andrea
Bianco, Luann
Van Ness, Peter H
Quagliarello, Vincent
Juthani-Mehta, Manisha
author_facet Datta, Rupak
Advani, Sonali
Rink, Andrea
Bianco, Luann
Van Ness, Peter H
Quagliarello, Vincent
Juthani-Mehta, Manisha
author_sort Datta, Rupak
collection PubMed
description Suspected urinary tract infection is a common indication for antimicrobial therapy in long-term care residents. We sought to characterize antimicrobial susceptibilities among urine isolates collected from women long-term care residents enrolled in a clinical trial across 21 long-term care facilities in Connecticut, United States of America between August 2012 and October 2015. Among 967 urine cultures collected from 175 women long-term care residents with and without suspected urinary tract infection, we identified 456 bacterial isolates. Escherichia coli (55.3%), Klebsiella (13.8%) and Enterococcus (8.3%) species were the predominant organisms identified. Among all 456 urine isolates, 68.1% were ciprofloxacin-susceptible, 77.2% were trimethoprim/sulfamethoxazole-susceptible, 86.3% were cefazolin-susceptible, and 72.6% were nitrofurantoin-susceptible. Among 252 Escherichia coli urine isolates, 60.2% were ciprofloxacin-susceptible, 73.7% were trimethoprim/ sulfamethoxazole-susceptible, 84.5% were cefazolin-susceptible, and 86.5% were nitrofurantoin-susceptible. These findings suggest that trimethoprim/sulfamethoxazole may be favorable empiric therapy while the urinary isolate is unknown, and nitrofurantoin may be optimal therapy for uncomplicated urinary tract infection due to Escherichia coli in women long-term care residents.
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spelling pubmed-62415322018-11-19 Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report Datta, Rupak Advani, Sonali Rink, Andrea Bianco, Luann Van Ness, Peter H Quagliarello, Vincent Juthani-Mehta, Manisha Open Access J Gerontol Geriatr Med Article Suspected urinary tract infection is a common indication for antimicrobial therapy in long-term care residents. We sought to characterize antimicrobial susceptibilities among urine isolates collected from women long-term care residents enrolled in a clinical trial across 21 long-term care facilities in Connecticut, United States of America between August 2012 and October 2015. Among 967 urine cultures collected from 175 women long-term care residents with and without suspected urinary tract infection, we identified 456 bacterial isolates. Escherichia coli (55.3%), Klebsiella (13.8%) and Enterococcus (8.3%) species were the predominant organisms identified. Among all 456 urine isolates, 68.1% were ciprofloxacin-susceptible, 77.2% were trimethoprim/sulfamethoxazole-susceptible, 86.3% were cefazolin-susceptible, and 72.6% were nitrofurantoin-susceptible. Among 252 Escherichia coli urine isolates, 60.2% were ciprofloxacin-susceptible, 73.7% were trimethoprim/ sulfamethoxazole-susceptible, 84.5% were cefazolin-susceptible, and 86.5% were nitrofurantoin-susceptible. These findings suggest that trimethoprim/sulfamethoxazole may be favorable empiric therapy while the urinary isolate is unknown, and nitrofurantoin may be optimal therapy for uncomplicated urinary tract infection due to Escherichia coli in women long-term care residents. 2018-05-22 2018-04 /pmc/articles/PMC6241532/ /pubmed/30465048 http://dx.doi.org/10.19080/OAJGGM.2018.04.555636 Text en This work is licensed under Creative Commons Attribution 4.0 License http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Datta, Rupak
Advani, Sonali
Rink, Andrea
Bianco, Luann
Van Ness, Peter H
Quagliarello, Vincent
Juthani-Mehta, Manisha
Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report
title Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report
title_full Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report
title_fullStr Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report
title_full_unstemmed Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report
title_short Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report
title_sort increased fluoroquinolone-susceptibility and preserved nitrofurantoin-susceptibility among escherichia coli urine isolates from women long-term care residents: a brief report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241532/
https://www.ncbi.nlm.nih.gov/pubmed/30465048
http://dx.doi.org/10.19080/OAJGGM.2018.04.555636
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