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Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection
Chronic hepatitis C virus (HCV) infection has been associated with both organ-specific and systemic autoimmune diseases, with cryoglobulinemia being the most frequent associated disease. Experimental, virologic, and clinical evidence have demon-strated a close association between HCV infection and s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedad Española de Sanidad Penitenciaria
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241927/ https://www.ncbi.nlm.nih.gov/pubmed/29364334 |
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author | Flores-Chávez, A. Carrion, J.A. Forns, X. Ramos-Casals, M. |
author_facet | Flores-Chávez, A. Carrion, J.A. Forns, X. Ramos-Casals, M. |
author_sort | Flores-Chávez, A. |
collection | PubMed |
description | Chronic hepatitis C virus (HCV) infection has been associated with both organ-specific and systemic autoimmune diseases, with cryoglobulinemia being the most frequent associated disease. Experimental, virologic, and clinical evidence have demon-strated a close association between HCV infection and some systemic autoimmune diseases, especially Sjögren’s syndrome, but also rheumatoid arthritis and lupus. A higher prevalence of hematological processes has also been described in patients with HCV infection, including cytopenias and lymphoproliferative disorders (B-cell lymphoma). In addition, patients with chronic HCV infection have a higher frequency of other extrahepatic manifestations including endocrine, metabolic and cardiovascular disorders that may worse the prognosis of patients, along with neuropsychiatric manifestations and general symptoms that have a significant influence on the quality of life of the patient. Direct-acting antiviral therapies (DAAs) that have recently begun to be used are providing the opportunity to effectively cure chronic HCV infection and reduce the burden of both hepatic and extrahepatic complications. |
format | Online Article Text |
id | pubmed-6241927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Sociedad Española de Sanidad Penitenciaria |
record_format | MEDLINE/PubMed |
spelling | pubmed-62419272019-01-15 Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection Flores-Chávez, A. Carrion, J.A. Forns, X. Ramos-Casals, M. Rev Esp Sanid Penit Revision Chronic hepatitis C virus (HCV) infection has been associated with both organ-specific and systemic autoimmune diseases, with cryoglobulinemia being the most frequent associated disease. Experimental, virologic, and clinical evidence have demon-strated a close association between HCV infection and some systemic autoimmune diseases, especially Sjögren’s syndrome, but also rheumatoid arthritis and lupus. A higher prevalence of hematological processes has also been described in patients with HCV infection, including cytopenias and lymphoproliferative disorders (B-cell lymphoma). In addition, patients with chronic HCV infection have a higher frequency of other extrahepatic manifestations including endocrine, metabolic and cardiovascular disorders that may worse the prognosis of patients, along with neuropsychiatric manifestations and general symptoms that have a significant influence on the quality of life of the patient. Direct-acting antiviral therapies (DAAs) that have recently begun to be used are providing the opportunity to effectively cure chronic HCV infection and reduce the burden of both hepatic and extrahepatic complications. Sociedad Española de Sanidad Penitenciaria 2017 /pmc/articles/PMC6241927/ /pubmed/29364334 Text en https://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Revision Flores-Chávez, A. Carrion, J.A. Forns, X. Ramos-Casals, M. Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection |
title | Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection |
title_full | Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection |
title_fullStr | Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection |
title_full_unstemmed | Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection |
title_short | Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection |
title_sort | extrahepatic manifestations associated with chronic hepatitis c virus infection |
topic | Revision |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241927/ https://www.ncbi.nlm.nih.gov/pubmed/29364334 |
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