Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

Obesity is a major driver of cancer, especially hepatocellular carcinoma (HCC). The prevailing view is that non-alcoholic steatohepatitis (NASH) and fibrosis or cirrhosis are required for HCC in obesity. Here, we report that NASH and fibrosis and HCC in obesity can be dissociated. We show that the o...

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Detalles Bibliográficos
Autores principales: Grohmann, Marcus, Wiede, Florian, Dodd, Garron T., Gurzov, Esteban N., Ooi, Geraldine J., Butt, Tariq, Rasmiena, Aliki A., Kaur, Supreet, Gulati, Twishi, Goh, Pei K., Treloar, Aislinn E., Archer, Stuart, Brown, Wendy A., Muller, Mathias, Watt, Matthew J., Ohara, Osamu, McLean, Catriona A., Tiganis, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242467/
https://www.ncbi.nlm.nih.gov/pubmed/30454647
http://dx.doi.org/10.1016/j.cell.2018.09.053

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