Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition

Carbonic anhydrases (CAs) have been linked to tumor progression, particularly membrane-bound CA isoform IX (CA IX). The role of CA IX in the context of breast cancer is to regulate the pH of the tumor microenvironment. In contrast to CA IX, expression of CA XII, specifically in breast cancer, is ass...

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Detalles Bibliográficos
Autores principales: Mboge, Mam Y., Chen, Zhijuan, Wolff, Alyssa, Mathias, John V., Tu, Chingkuang, Brown, Kevin D., Bozdag, Murat, Carta, Fabrizio, Supuran, Claudiu T., McKenna, Robert, Frost, Susan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242694/
https://www.ncbi.nlm.nih.gov/pubmed/30452451
http://dx.doi.org/10.1371/journal.pone.0207417

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