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Recently highlighted nutraceuticals for preventive management of osteoarthritis

Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage with limited treatment options. This reality encourages clinicians to suggest preventive measures to delay and contain the outbreak of the pathological conditions. Articular cartilage and synovium suffering from OA are char...

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Autores principales: Ravalli, Silvia, Szychlinska, Marta Anna, Leonardi, Rosalia Maria, Musumeci, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242728/
https://www.ncbi.nlm.nih.gov/pubmed/30479972
http://dx.doi.org/10.5312/wjo.v9.i11.255
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author Ravalli, Silvia
Szychlinska, Marta Anna
Leonardi, Rosalia Maria
Musumeci, Giuseppe
author_facet Ravalli, Silvia
Szychlinska, Marta Anna
Leonardi, Rosalia Maria
Musumeci, Giuseppe
author_sort Ravalli, Silvia
collection PubMed
description Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage with limited treatment options. This reality encourages clinicians to suggest preventive measures to delay and contain the outbreak of the pathological conditions. Articular cartilage and synovium suffering from OA are characterised by an inflammatory state and by significant oxidative stress, responsible for pain, swelling and loss of mobility in the advanced stages. This review will focus on the ability of olive oil to exert positive effects on the entire joint to reduce pro-inflammatory cytokine release and increase lubricin synthesis, olive leaf extract, since it maintains lubrication by stimulating high molecular weight hyaluronan synthesis in synovial cells, curcumin, which delays the start of pathological cartilage breakdown, sanguinarine, which downregulates catabolic proteases, vitamin D for its capacity to influence the oxidative and pro-inflammatory environment, and carnosic acid as an inducer of heme oxygenase-1, which helps preserve cartilage degeneration. These molecules, considered as natural dietary supplements, appear like a cutting-edge answer to this tough health problem, playing a major role in controlling homeostatic balance loss and slowing down the pathology progression. Natural or food-derived molecules that are able to exert potential therapeutic effects are known as “nutraceutical”, resulting from the combination of the words “nutrition” and “pharmaceutical”. These compounds have gained popularity due to their easy availability, which represents a huge advantage for food and pharmaceutical industries. In addition, the chronic nature of OA implies the use of pharmacological compounds with proven long-term safety, especially because current treatments like nonsteroidal anti-inflammatory drugs and analgesics improve pain relief but have no effect on degenerative progression and can also cause serious side effects.
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spelling pubmed-62427282018-11-26 Recently highlighted nutraceuticals for preventive management of osteoarthritis Ravalli, Silvia Szychlinska, Marta Anna Leonardi, Rosalia Maria Musumeci, Giuseppe World J Orthop Minireviews Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage with limited treatment options. This reality encourages clinicians to suggest preventive measures to delay and contain the outbreak of the pathological conditions. Articular cartilage and synovium suffering from OA are characterised by an inflammatory state and by significant oxidative stress, responsible for pain, swelling and loss of mobility in the advanced stages. This review will focus on the ability of olive oil to exert positive effects on the entire joint to reduce pro-inflammatory cytokine release and increase lubricin synthesis, olive leaf extract, since it maintains lubrication by stimulating high molecular weight hyaluronan synthesis in synovial cells, curcumin, which delays the start of pathological cartilage breakdown, sanguinarine, which downregulates catabolic proteases, vitamin D for its capacity to influence the oxidative and pro-inflammatory environment, and carnosic acid as an inducer of heme oxygenase-1, which helps preserve cartilage degeneration. These molecules, considered as natural dietary supplements, appear like a cutting-edge answer to this tough health problem, playing a major role in controlling homeostatic balance loss and slowing down the pathology progression. Natural or food-derived molecules that are able to exert potential therapeutic effects are known as “nutraceutical”, resulting from the combination of the words “nutrition” and “pharmaceutical”. These compounds have gained popularity due to their easy availability, which represents a huge advantage for food and pharmaceutical industries. In addition, the chronic nature of OA implies the use of pharmacological compounds with proven long-term safety, especially because current treatments like nonsteroidal anti-inflammatory drugs and analgesics improve pain relief but have no effect on degenerative progression and can also cause serious side effects. Baishideng Publishing Group Inc 2018-11-18 /pmc/articles/PMC6242728/ /pubmed/30479972 http://dx.doi.org/10.5312/wjo.v9.i11.255 Text en ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Ravalli, Silvia
Szychlinska, Marta Anna
Leonardi, Rosalia Maria
Musumeci, Giuseppe
Recently highlighted nutraceuticals for preventive management of osteoarthritis
title Recently highlighted nutraceuticals for preventive management of osteoarthritis
title_full Recently highlighted nutraceuticals for preventive management of osteoarthritis
title_fullStr Recently highlighted nutraceuticals for preventive management of osteoarthritis
title_full_unstemmed Recently highlighted nutraceuticals for preventive management of osteoarthritis
title_short Recently highlighted nutraceuticals for preventive management of osteoarthritis
title_sort recently highlighted nutraceuticals for preventive management of osteoarthritis
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242728/
https://www.ncbi.nlm.nih.gov/pubmed/30479972
http://dx.doi.org/10.5312/wjo.v9.i11.255
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