Cargando…

Bioavailability of a novel form of silicon supplement

In this study, we assessed uptake and potential efficacy of a novel, pH neutral form of silicon supplement in vitro and using broiler chickens as a model species. In vitro bioavailability of this supplement was significantly higher than other commercial supplements tested, all of which claim availab...

Descripción completa

Detalles Bibliográficos
Autores principales: Scholey, D. V., Belton, D. J., Burton, E. J., Perry, C. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242837/
https://www.ncbi.nlm.nih.gov/pubmed/30451899
http://dx.doi.org/10.1038/s41598-018-35292-9
_version_ 1783371847231864832
author Scholey, D. V.
Belton, D. J.
Burton, E. J.
Perry, C. C.
author_facet Scholey, D. V.
Belton, D. J.
Burton, E. J.
Perry, C. C.
author_sort Scholey, D. V.
collection PubMed
description In this study, we assessed uptake and potential efficacy of a novel, pH neutral form of silicon supplement in vitro and using broiler chickens as a model species. In vitro bioavailability of this supplement was significantly higher than other commercial supplements tested, all of which claim available silica content. To confirm bioavailability of the new supplement in vivo, a broiler chick feeding trial reported blood uptake that was significantly higher than a Bamboo-derived silicon supplement. We assessed dose response of the novel supplement in a further study with increased dose related levels of silicon being detected in the blood and tibia. We found tibia and foot ash residue as a percentage of dry mass was higher with inclusion of the novel supplement in the diet, particularly in young birds and that this was followed by significant increase in tibia breaking strength. This novel supplement may therefore have applications in the improvement of bone integrity, with implications for the reduction of lameness in broilers. These results indicate the novel silica supplement is readily absorbed in chicks, and transported in the blood supply to sites such as the skeleton due to it being present in a non-condensed, monomeric form. There is potential for wider application of this silica supplement in other species where bone breakages are a problem, including high performance sport.
format Online
Article
Text
id pubmed-6242837
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-62428372018-11-27 Bioavailability of a novel form of silicon supplement Scholey, D. V. Belton, D. J. Burton, E. J. Perry, C. C. Sci Rep Article In this study, we assessed uptake and potential efficacy of a novel, pH neutral form of silicon supplement in vitro and using broiler chickens as a model species. In vitro bioavailability of this supplement was significantly higher than other commercial supplements tested, all of which claim available silica content. To confirm bioavailability of the new supplement in vivo, a broiler chick feeding trial reported blood uptake that was significantly higher than a Bamboo-derived silicon supplement. We assessed dose response of the novel supplement in a further study with increased dose related levels of silicon being detected in the blood and tibia. We found tibia and foot ash residue as a percentage of dry mass was higher with inclusion of the novel supplement in the diet, particularly in young birds and that this was followed by significant increase in tibia breaking strength. This novel supplement may therefore have applications in the improvement of bone integrity, with implications for the reduction of lameness in broilers. These results indicate the novel silica supplement is readily absorbed in chicks, and transported in the blood supply to sites such as the skeleton due to it being present in a non-condensed, monomeric form. There is potential for wider application of this silica supplement in other species where bone breakages are a problem, including high performance sport. Nature Publishing Group UK 2018-11-19 /pmc/articles/PMC6242837/ /pubmed/30451899 http://dx.doi.org/10.1038/s41598-018-35292-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Scholey, D. V.
Belton, D. J.
Burton, E. J.
Perry, C. C.
Bioavailability of a novel form of silicon supplement
title Bioavailability of a novel form of silicon supplement
title_full Bioavailability of a novel form of silicon supplement
title_fullStr Bioavailability of a novel form of silicon supplement
title_full_unstemmed Bioavailability of a novel form of silicon supplement
title_short Bioavailability of a novel form of silicon supplement
title_sort bioavailability of a novel form of silicon supplement
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242837/
https://www.ncbi.nlm.nih.gov/pubmed/30451899
http://dx.doi.org/10.1038/s41598-018-35292-9
work_keys_str_mv AT scholeydv bioavailabilityofanovelformofsiliconsupplement
AT beltondj bioavailabilityofanovelformofsiliconsupplement
AT burtonej bioavailabilityofanovelformofsiliconsupplement
AT perrycc bioavailabilityofanovelformofsiliconsupplement