Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function

The metabolic checkpoint kinase mechanistic/mammalian target of rapamycin (mTOR) regulates natural killer (NK) cell development and function, but the exact underlying mechanisms remain unclear. Here, we show, via conditional deletion of Raptor (mTORC1) or Rictor (mTORC2), that mTORC1 and mTORC2 prom...

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Detalles Bibliográficos
Autores principales: Wang, Fangjie, Meng, Meng, Mo, Banghui, Yang, Yao, Ji, Yan, Huang, Pei, Lai, Wenjing, Pan, Xiaodong, You, Tingting, Luo, Hongqin, Guan, Xiao, Deng, Yafei, Yuan, Shunzong, Chu, Jianhong, Namaka, Michael, Hughes, Tiffany, Ye, Lilin, Yu, Jianhua, Li, Xiaohui, Deng, Youcai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242843/
https://www.ncbi.nlm.nih.gov/pubmed/30451838
http://dx.doi.org/10.1038/s41467-018-07277-9

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