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Memory formation and long-term maintenance of IL-7Rα(+) ILC1s via a lymph node-liver axis

Natural killer (NK) cells are reported to have immunological memory, with CD49a(+) liver-resident NK cells shown to confer hapten-specific memory responses, but how this memory is induced or maintained is unclear. Here we show that memory type I innate lymphoid cells (ILC1s), which express IL-7Rα, a...

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Autores principales: Wang, Xianwei, Peng, Hui, Cong, Jingjing, Wang, Xuefu, Lian, Zhexiong, Wei, Haiming, Sun, Rui, Tian, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242895/
https://www.ncbi.nlm.nih.gov/pubmed/30451860
http://dx.doi.org/10.1038/s41467-018-07405-5
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author Wang, Xianwei
Peng, Hui
Cong, Jingjing
Wang, Xuefu
Lian, Zhexiong
Wei, Haiming
Sun, Rui
Tian, Zhigang
author_facet Wang, Xianwei
Peng, Hui
Cong, Jingjing
Wang, Xuefu
Lian, Zhexiong
Wei, Haiming
Sun, Rui
Tian, Zhigang
author_sort Wang, Xianwei
collection PubMed
description Natural killer (NK) cells are reported to have immunological memory, with CD49a(+) liver-resident NK cells shown to confer hapten-specific memory responses, but how this memory is induced or maintained is unclear. Here we show that memory type I innate lymphoid cells (ILC1s), which express IL-7Rα, are generated in the lymph nodes (LNs) and require IL-7R signaling to maintain their longevity in the liver. Hapten sensitization initiates CXCR3-dependent recruitment of IL-7Rα(+) ILC1s into skin-draining LNs, where they are primed and acquire hapten-specific memory potential. Memory IL-7Rα(+) ILC1s then exit draining LNs and are preferentially recruited, via CXCR6, to reside in the liver. Moreover, long-term blockade of IL-7R signaling significantly reduces ILC1-mediated memory responses. Thus, our results identify a memory IL-7Rα(+) ILC1 population and reveal a LN-liver axis that is essential for ILC1 memory generation and long-term maintenance.
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spelling pubmed-62428952018-11-21 Memory formation and long-term maintenance of IL-7Rα(+) ILC1s via a lymph node-liver axis Wang, Xianwei Peng, Hui Cong, Jingjing Wang, Xuefu Lian, Zhexiong Wei, Haiming Sun, Rui Tian, Zhigang Nat Commun Article Natural killer (NK) cells are reported to have immunological memory, with CD49a(+) liver-resident NK cells shown to confer hapten-specific memory responses, but how this memory is induced or maintained is unclear. Here we show that memory type I innate lymphoid cells (ILC1s), which express IL-7Rα, are generated in the lymph nodes (LNs) and require IL-7R signaling to maintain their longevity in the liver. Hapten sensitization initiates CXCR3-dependent recruitment of IL-7Rα(+) ILC1s into skin-draining LNs, where they are primed and acquire hapten-specific memory potential. Memory IL-7Rα(+) ILC1s then exit draining LNs and are preferentially recruited, via CXCR6, to reside in the liver. Moreover, long-term blockade of IL-7R signaling significantly reduces ILC1-mediated memory responses. Thus, our results identify a memory IL-7Rα(+) ILC1 population and reveal a LN-liver axis that is essential for ILC1 memory generation and long-term maintenance. Nature Publishing Group UK 2018-11-19 /pmc/articles/PMC6242895/ /pubmed/30451860 http://dx.doi.org/10.1038/s41467-018-07405-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wang, Xianwei
Peng, Hui
Cong, Jingjing
Wang, Xuefu
Lian, Zhexiong
Wei, Haiming
Sun, Rui
Tian, Zhigang
Memory formation and long-term maintenance of IL-7Rα(+) ILC1s via a lymph node-liver axis
title Memory formation and long-term maintenance of IL-7Rα(+) ILC1s via a lymph node-liver axis
title_full Memory formation and long-term maintenance of IL-7Rα(+) ILC1s via a lymph node-liver axis
title_fullStr Memory formation and long-term maintenance of IL-7Rα(+) ILC1s via a lymph node-liver axis
title_full_unstemmed Memory formation and long-term maintenance of IL-7Rα(+) ILC1s via a lymph node-liver axis
title_short Memory formation and long-term maintenance of IL-7Rα(+) ILC1s via a lymph node-liver axis
title_sort memory formation and long-term maintenance of il-7rα(+) ilc1s via a lymph node-liver axis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242895/
https://www.ncbi.nlm.nih.gov/pubmed/30451860
http://dx.doi.org/10.1038/s41467-018-07405-5
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