Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

It was already described that genetic inhibition of NUPR1 induces tumor growth arrest. In this paper we studied the metabolism changes after NUPR1 downregulation in pancreatic cancer cells, which results in a significant decrease of OXPHOS activity with a concomitant lower ATP production which prece...

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Detalles Bibliográficos
Autores principales: Santofimia-Castaño, Patricia, Lan, Wenjun, Bintz, Jennifer, Gayet, Odile, Carrier, Alice, Lomberk, Gwen, Neira, José Luis, González, Antonio, Urrutia, Raul, Soubeyran, Philippe, Iovanna, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242935/
https://www.ncbi.nlm.nih.gov/pubmed/30451898
http://dx.doi.org/10.1038/s41598-018-35020-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242935/
https://www.ncbi.nlm.nih.gov/pubmed/30451898
http://dx.doi.org/10.1038/s41598-018-35020-3

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