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Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis
It was already described that genetic inhibition of NUPR1 induces tumor growth arrest. In this paper we studied the metabolism changes after NUPR1 downregulation in pancreatic cancer cells, which results in a significant decrease of OXPHOS activity with a concomitant lower ATP production which prece...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242935/ https://www.ncbi.nlm.nih.gov/pubmed/30451898 http://dx.doi.org/10.1038/s41598-018-35020-3 |