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Lowering Etoposide Doses Shifts Cell Demise From Caspase-Dependent to Differentiation and Caspase-3-Independent Apoptosis via DNA Damage Response, Inducing AML Culture Extinction

Cytotoxic chemotherapy, still the most widely adopted anticancer treatment, aims at eliminating cancer cells inducing apoptosis with DNA damaging agents, exploiting the differential replication rate of cancer vs. normal cells; efficiency is evaluated in terms of extent of induced apoptosis, which de...

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Detalles Bibliográficos
Autores principales:	Bruni, Emanuele, Reichle, Albrecht, Scimeca, Manuel, Bonanno, Elena, Ghibelli, Lina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243040/ https://www.ncbi.nlm.nih.gov/pubmed/30483138 http://dx.doi.org/10.3389/fphar.2018.01307

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