The Development of an AAV-Based CRISPR SaCas9 Genome Editing System That Can Be Delivered to Neurons in vivo and Regulated via Doxycycline and Cre-Recombinase

The RNA-guided Cas9 nuclease, from the type II prokaryotic clustered regularly interspersed short palindromic repeats (CRISPR) adaptive immune system, has been adapted by scientists to enable site specific genome editing of eukaryotic cells both in vitro and in vivo. Previously, we reported the deve...

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Detalles Bibliográficos
Autores principales: Kumar, Namrata, Stanford, William, de Solis, Christopher, Aradhana, Abraham, Nigel D., Dao, Trieu-Mi J., Thaseen, Sadiqa, Sairavi, Anusha, Gonzalez, Cuauhtemoc Ulises, Ploski, Jonathan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243075/
https://www.ncbi.nlm.nih.gov/pubmed/30483052
http://dx.doi.org/10.3389/fnmol.2018.00413

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