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Metformin and Type 2 Diabetes Prevention

IN BRIEF Metformin, an established therapy for the treatment of type 2 diabetes, has demonstrated safety and effectiveness in the prevention or delay of type 2 diabetes in people at high risk. The Diabetes Prevention Program randomized clinical trial demonstrated that intensive lifestyle interventio...

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Detalles Bibliográficos
Autores principales: Aroda, Vanita R., Ratner, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243218/
https://www.ncbi.nlm.nih.gov/pubmed/30510389
http://dx.doi.org/10.2337/ds18-0020
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author Aroda, Vanita R.
Ratner, Robert E.
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Ratner, Robert E.
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description IN BRIEF Metformin, an established therapy for the treatment of type 2 diabetes, has demonstrated safety and effectiveness in the prevention or delay of type 2 diabetes in people at high risk. The Diabetes Prevention Program randomized clinical trial demonstrated that intensive lifestyle intervention and metformin therapy reduced progression to diabetes by 58 and 31%, respectively, compared to placebo in people at risk of type 2 diabetes. Although lifestyle intervention was beneficial in all groups, metformin had a selectively greater effect in those who were more obese, had a higher fasting glucose, had a history of gestational diabetes, or were younger. Long-term effects included an 18% diabetes reduction with metformin compared to placebo over 15 years, a reduction in microvascular complications among those who did not progress to diabetes (without difference among treatment arms), and suggestion by coronary calcium assessment of a possible impact on atherosclerosis in men. Although long-term follow-up to assess later-stage outcomes is underway, current efforts to address gaps in evidence and translation remain of significant public health interest.
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spelling pubmed-62432182019-11-01 Metformin and Type 2 Diabetes Prevention Aroda, Vanita R. Ratner, Robert E. Diabetes Spectr From Research to Practice IN BRIEF Metformin, an established therapy for the treatment of type 2 diabetes, has demonstrated safety and effectiveness in the prevention or delay of type 2 diabetes in people at high risk. The Diabetes Prevention Program randomized clinical trial demonstrated that intensive lifestyle intervention and metformin therapy reduced progression to diabetes by 58 and 31%, respectively, compared to placebo in people at risk of type 2 diabetes. Although lifestyle intervention was beneficial in all groups, metformin had a selectively greater effect in those who were more obese, had a higher fasting glucose, had a history of gestational diabetes, or were younger. Long-term effects included an 18% diabetes reduction with metformin compared to placebo over 15 years, a reduction in microvascular complications among those who did not progress to diabetes (without difference among treatment arms), and suggestion by coronary calcium assessment of a possible impact on atherosclerosis in men. Although long-term follow-up to assess later-stage outcomes is underway, current efforts to address gaps in evidence and translation remain of significant public health interest. American Diabetes Association 2018-11 /pmc/articles/PMC6243218/ /pubmed/30510389 http://dx.doi.org/10.2337/ds18-0020 Text en © 2018 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0 for details.
spellingShingle From Research to Practice
Aroda, Vanita R.
Ratner, Robert E.
Metformin and Type 2 Diabetes Prevention
title Metformin and Type 2 Diabetes Prevention
title_full Metformin and Type 2 Diabetes Prevention
title_fullStr Metformin and Type 2 Diabetes Prevention
title_full_unstemmed Metformin and Type 2 Diabetes Prevention
title_short Metformin and Type 2 Diabetes Prevention
title_sort metformin and type 2 diabetes prevention
topic From Research to Practice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243218/
https://www.ncbi.nlm.nih.gov/pubmed/30510389
http://dx.doi.org/10.2337/ds18-0020
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